Context The effect of kaempferol, a regulator of oestrogen receptors, on atherosclerosis (AS)
and the underlying mechanism is elusive. Objective To explore the effect and mechanism of …

Kaempferol is a dietary flavonoid that is thought to function as a selective estrogen receptor
modulator. In this study, we established that kaempferol also functions as an inverse agonist …

Over recent years, an increasing number of studies have confirmed that the occurrence and
development of vascular pathological changes are closely related to oxidative stress and the …

Background Atherosclerosis has been widely accepted as an inflammatory disease of
vascular, adhesion molecules play an important role in the early progression of it. The aim of …

Heart failure characterized by cardiac remodeling is a global problem. Angiotensin II (Ang II)
induces cardiac inflammation and oxidative stress, which also is implicated in the …

Background Atherosclerosis, inflammatory disease, is a major reason for cardiovascular
diseases and stroke. Kaempferol (Kae) has been well-documented to have pharmacological …

Previously, we reported that cAMP/PKA signaling is involved in GPER-mediated coronary
relaxation by activating MLCP via inhibition of RhoA pathway. In the current study, we tested …

Inflammation and apoptosis of vascular endothelial cells play a key role in the occurrence
and development of atherosclerosis (AS), and the AMPK/mTOR/Nrf2 signaling pathway …

Genistein, a soy isoflavone, has received wide attention for its potential to improve vascular
function, but the mechanism of this effect is unclear. Here, we report that genistein at …

Natural products possess pleiotropic cardiovascular protective effects owing to their anti-
oxidation, anti-inflammation and anti-thrombotic properties. Kaempferol,(3, 5, 7-trihydroxy-2 …