HIV-1 integrase (IN) is a validated therapeutic target for antiviral drug design. However, the
emergence of viral strains resistant to clinically studied IN inhibitors demands the discovery …

A novel series of HIV-1 integrase inhibitors was synthesized and tested in both in vitro and
ex vivo assays. These inhibitors are featured by the presence of a quinoline subunit and an …

HIV-1 integrase (IN) is one of three enzymes encoded by the HIV genome and is essential
for viral replication, and HIV-1 IN inhibitors have emerged as a new promising class of …

A series of 2-hydroxy-1, 3-dioxoisoquinoline-4-carboxamides featuring an N-hydroxyimide
chelating functionality was evaluated for their inhibitory properties against human …

Existing AIDS therapies are out of reach for most HIV-infected people in developing
countries and, where available, they are limited by their toxicity and their cost. New anti-HIV …

HIV integrase is one of the three enzymes encoded by HIV genome and is essential for viral
replication, but integrase inhibitors as marketed drugs have just very recently started to …

HIV-1 integrase (IN) is one of three enzymes encoded by the HIV genome and is essential
for viral replication. Recently, HIV-1 IN inhibitors have emerged as a new promising class of …

6-Endo-dig-cyclization is an efficient method for the synthesis of 1, 2-dihydroisoquinolines.
We have synthesized few 1, 2-dihydroisoquinolines having different functionality at the C-1 …

This communication details both the syntheses and biological evaluation of a novel class of
HIV-1 integrase inhibitors. When the quinoline moiety is replaced with the quinoxoline …

HIV integrase became an important target for drug development more than twenty years
ago. However, progress has been hampered by the lack of assays suitable for high …