Aberrant energy metabolism not only endows tumor cells with unlimited proliferative
capacity but also contributes to the establishment of the glucose-deficient/lactate-rich …

The intense metabolism of cancer cells leads to hypoxia and lack of crucial nutrients in the
tumor microenvironment, which hinders the function of immune cells. We designed a …

Cancer immunotherapy has become an established therapeutic paradigm in oncologic
therapy, but its therapeutic efficacy remains unsatisfactory in the majority of cancer patients …

Despite the promise of tumor starvation therapies, they are often associated with nonspecific
and incomplete energy blockade. Here, a novel paradigm of starvation therapy is proposed …

Abstract Cancer-associated fibroblasts (CAFs)-mediated metabolic support plays a vital role
in tumorigenesis. The metabolic network between cancer cells and CAFs may serve as …

Aberrant tumor metabolic activities not only promote the aggressiveness and proliferation of
tumor cells in the harsh microenvironment in vivo, but also contribute to immune cell …

Lactate plays a critical role in tumorigenesis, invasion and metastasis. Exhausting lactate in
tumors holds great promise for the reversal of the immunosuppressive tumor …

Mutation burden, hypoxia, and immunoediting contribute to altered metabolic profiles in
tumor cells, resulting in a tumor microenvironment (TME) characterized by accumulation of …

Cancer cells, like all other cells in the body, require energy to perform basic functions,
develop, and survive. Glucose metabolism (GM) is the primary energy source for cancer …

Tumor cells reprogram the metabolic pathways to acquire abundant nutrients and sustain
malignant proliferation. This fierce metabolic competition in tumor ecosystem has been …