The ability to model physiological systems through 3D neural in-vitro systems may enable
new treatments for various diseases while lowering the need for challenging animal and …

Traumatic brain injury (TBI) remains a prominent public health concern despite several
decades of attempts to develop therapies for the associated neurological and cognitive …

Modeling traumatic brain injury (TBI) has been a challenge. Rodent and cellular models
have provided relevant contributions despite their limitations. Here, we present a protocol for …

Traumatic brain injury (TBI) is a head injury that disrupts the normal brain structure and
function. TBI has been extensively studied using various in vitro and in vivo models. Most of …

Stem cell-derived brain organoids provide a powerful platform for systematic studies of
tissue functional architecture and the development of personalized therapies. Here, we …

Fundamental questions about patient heterogeneity and human-specific pathophysiology
currently obstruct progress towards a therapy for traumatic brain injury (TBI). Human in vitro …

Brain organoids are three-dimensional, tissue-engineered neural models derived from
induced pluripotent stem cells that enable studies of neurodevelopmental and disease …

Brain organoids have emerged as a novel model system for neural development,
neurodegenerative diseases, and human-based drug screening. However, the …

Understanding the complexities of the human brain's function in health and disease is a
formidable challenge in neuroscience. While traditional models like animals offer valuable …

Advances in translational neuroscience require experimental models recapitulating the
complexity of the human brain. In contrast to conventional 2D cell culture models and animal …