Eukaryotes are characterized by endomembranes that are connected by vesicular transport
along secretory and endocytic pathways. The compositional differences between the various …

Sphingolipids constitute a sizeable fraction of the membrane lipids in all eukaryotes and are
indispensable for eukaryotic life. First of all, the involvement of sphingolipids in organizing …

Until some 15 years ago, sphingolipids were generally believed to protect the cell surface
against harmful factors in the environment by forming a mechanically stable and chemically …

The intracellular routes of sphingolipid trafficking are related to the compartmentalized
nature of sphingolipid metabolism, with synthesis beginning in the endoplasmic reticulum …

Recent cell biological studies suggest that sphingolipids and cholesterol may cluster in
biomembranes to form raft-like microdomains. Such lipid domains are postulated to function …

Sphingolipids are ubiquitous components of eukaryotic cell membranes, where they play
important roles in intracellular signaling and in membrane structure. Even though the …

Sphingolipids and their metabolites play key cellular roles both as structural components of
membranes and as signaling molecules that mediate responses to physiologic cues and …

In recent years, a huge interest in sphingolipid-and cholesterol-enriched membrane
domains has risen, after their involvement in fundamental membrane-associated events …

Recent studies on the endocytic itinerary of glycosphingolipids (GSLs) in sphingolipid
storage disease (SLSD) fibroblasts have yielded new insights into the mechanisms …

Glycosphingolipids, a family of heterogeneous lipids with biophysical properties conserved
from fungi to mammals, are key components of cellular membranes. Because of their tightly …