Anti-allodynic and medullary modulatory effects of a single dose of delta-9-tetrahydrocannabinol (THC) in neuropathic rats tolerant to morphine
L Pearl-Dowler, L Posa, M Lopez-Canul… - Progress in Neuro …, 2023 - Elsevier
Neuropathic pain (NP) is often treated with opioids, the prolonged use of which causes
tolerance to their analgesic effect and can potentially cause death by overdose. The …
tolerance to their analgesic effect and can potentially cause death by overdose. The …
Oral efficacy of Δ (9)-tetrahydrocannabinol and cannabidiol in a mouse neuropathic pain model
VA Mitchell, J Harley, SL Casey, AC Vaughan… - …, 2021 - Elsevier
The psychoactive and non-psychoactive constituents of cannabis, Δ9-tetrahydrocannabinol
(THC) and cannabidiol (CBD), have synergistic analgesic efficacy in animal models of …
(THC) and cannabidiol (CBD), have synergistic analgesic efficacy in animal models of …
Cannabinoid receptor-mediated antinociception with acetaminophen drug combinations in rats with neuropathic spinal cord injury pain
AT Hama, J Sagen - Neuropharmacology, 2010 - Elsevier
Pre-clinical evidence demonstrates that neuropathic spinal cord injury (SCI) pain is
maintained by a number of neurobiological mechanisms, suggesting that treatments …
maintained by a number of neurobiological mechanisms, suggesting that treatments …
Suppression of neuropathic pain behavior in rats by a non-psychotropic synthetic cannabinoid with NMDA receptor-blocking properties
R Zeltser, Z Seltzer, A Eisen, JJ Feigenbaum… - Pain, 1991 - journals.lww.com
HU211 is a novel synthetic derivative of tetrahydro-cannabinol (THC), the active marijuana
ingredient. The stereochemistry of HU211 is enantiomeric to that of THC. In contrast to THC …
ingredient. The stereochemistry of HU211 is enantiomeric to that of THC. In contrast to THC …
[HTML][HTML] Antinociceptive and abuse potential effects of cannabinoid/opioid combinations in a chronic pain model in rats
Chronic pain is a persistent and debilitating health problem. Although the use of analgesics
such as opioids is useful in mitigating pain, their prolonged use is associated with unwanted …
such as opioids is useful in mitigating pain, their prolonged use is associated with unwanted …
No antinociceptive synergy between morphine and delta-9-tetrahydrocannabinol in male and female rats with persistent inflammatory pain
SC Britch, RM Craft - Behavioural pharmacology, 2021 - journals.lww.com
Studies have demonstrated antinociceptive synergy between morphine and delta-9-
tetrahydrocannabinol (THC) in animals, but whether such synergy occurs against all types of …
tetrahydrocannabinol (THC) in animals, but whether such synergy occurs against all types of …
Effects of coadministration of cannabinoids and morphine on nociceptive behaviour, brain monoamines and HPA axis activity in a rat model of persistent pain
DP Finn, SRG Beckett, CH Roe, A Madjd… - European Journal of …, 2004 - Wiley Online Library
The antinociceptive effects of Δ9‐tetrahydrocannabinol (Δ9‐THC) have been widely
described; however, its therapeutic potential may be limited by secondary effects. We …
described; however, its therapeutic potential may be limited by secondary effects. We …
Effects of NMDA receptor blockade and nitric oxide synthase inhibition on the acute and chronic actions of Δ9-tetrahydrocannabinol in mice
SN Thorat, HN Bhargava - Brain research, 1994 - Elsevier
The present studies examined the hypothesis that the N-methyl-d-aspartate (NMDA)
receptor-nitric oxide (NO) pathway might be involved in the acute and chronic actions of Δ 9 …
receptor-nitric oxide (NO) pathway might be involved in the acute and chronic actions of Δ 9 …
THC and gabapentin interactions in a mouse neuropathic pain model
N Atwal, SL Casey, VA Mitchell, CW Vaughan - Neuropharmacology, 2019 - Elsevier
Clinical studies have shown that the major psychoactive ingredient of Cannabis sativa Δ9-
tetrahydrocannabinol (THC) has some analgesic efficacy in neuropathic pain states …
tetrahydrocannabinol (THC) has some analgesic efficacy in neuropathic pain states …
A role for central cannabinoid and opioid systems in peripheral Δ9-tetrahydrocannabinol-induced analgesia in mice
I Reche, JA Fuentes, M Ruiz-Gayo - European journal of pharmacology, 1996 - Elsevier
Δ9-tetrahydrocannabinol elicits analgesia in rodents by both spinal and supraspinal
mechanisms. Pharmacological data point to a link between cannabinoids and the opioid …
mechanisms. Pharmacological data point to a link between cannabinoids and the opioid …