Neuropathic pain (NP) is often treated with opioids, the prolonged use of which causes
tolerance to their analgesic effect and can potentially cause death by overdose. The …

The psychoactive and non-psychoactive constituents of cannabis, Δ9-tetrahydrocannabinol
(THC) and cannabidiol (CBD), have synergistic analgesic efficacy in animal models of …

Pre-clinical evidence demonstrates that neuropathic spinal cord injury (SCI) pain is
maintained by a number of neurobiological mechanisms, suggesting that treatments …

HU211 is a novel synthetic derivative of tetrahydro-cannabinol (THC), the active marijuana
ingredient. The stereochemistry of HU211 is enantiomeric to that of THC. In contrast to THC …

Chronic pain is a persistent and debilitating health problem. Although the use of analgesics
such as opioids is useful in mitigating pain, their prolonged use is associated with unwanted …

Studies have demonstrated antinociceptive synergy between morphine and delta-9-
tetrahydrocannabinol (THC) in animals, but whether such synergy occurs against all types of …

The antinociceptive effects of Δ9‐tetrahydrocannabinol (Δ9‐THC) have been widely
described; however, its therapeutic potential may be limited by secondary effects. We …

The present studies examined the hypothesis that the N-methyl-d-aspartate (NMDA)
receptor-nitric oxide (NO) pathway might be involved in the acute and chronic actions of Δ 9 …

Clinical studies have shown that the major psychoactive ingredient of Cannabis sativa Δ9-
tetrahydrocannabinol (THC) has some analgesic efficacy in neuropathic pain states …

Δ9-tetrahydrocannabinol elicits analgesia in rodents by both spinal and supraspinal
mechanisms. Pharmacological data point to a link between cannabinoids and the opioid …