Aggregated α-synuclein proteins form brain lesions that are hallmarks of neurodegenerative
synucleinopathies, and oxidative stress has been implicated in the pathogenesis of some of …

To elucidate the role of the synaptic protein α-synuclein in neurodegenerative disorders,
transgenic mice expressing wild-type human α-synuclein were generated. Neuronal …

Oligomeric species populated during the aggregation process of α-synuclein have been
linked to neuronal impairment in Parkinson's disease and related neurodegenerative …

The substantia nigra in Parkinson's disease (PD) is depleted of dopaminergic neurons and
contains fibrillar Lewy bodies comprising primarily α-synuclein. We screened a library to …

Reactive nitrogen species may play a mechanistic role in neurodegenerative diseases by
posttranslationally altering normal brain proteins. In support of this hypothesis, we …

Intracellular proteinaceous aggregates are hallmarks of many common neurodegenerative
disorders, and recent studies have shown that α-synuclein is a major component of several …

Brain lesions containing filamentous and aggregated α-synuclein are hallmarks of
neurodegenerative synucleinopathies. Oxidative stress has been implicated in the formation …

Alpha-synuclein is implicated in several neurodegenerative disorders, such as Parkinson's
disease and multiple system atrophy, yet its functions remain obscure. When expressed in …

Several neurodegenerative disorders are characterized by intracellular protein
accumulations or inclusions, such as the Lewy bodies of Parkinson's disease. Although little …

Aberrant α-synuclein degradation is implicated in Parkinson's disease pathogenesis
because the protein accumulates in the Lewy inclusion bodies associated with the disease …