Droplet microfluidics for single‐molecule and single‐cell analysis in research, diagnosis, and therapy

J Sanchez Barea, DK Kang - Bulletin of the Korean Chemical …, 2024 - Wiley Online Library
During the last decade, molecular diagnostics has become increasingly important,
especially during the SARS‐CoV‐2 pandemic. Advances in droplet‐based microfluidics …

Advances of droplet-based microfluidics in drug discovery

Y Wang, Z Chen, F Bian, L Shang, K Zhu… - Expert Opinion on Drug …, 2020 - Taylor & Francis
Introduction Drug discovery through a large number of candidates with nearly unlimited
possibilities is laborious, time-consuming, and incurs massive costs. It thus calls for fast and …

Characterizing Theta-Emitter Generation for Use in Microdroplet Reactions

JB Hatvany, ELP Olsen… - Journal of the American …, 2024 - ACS Publications
Theta emitters are useful for generating microdroplets for rapid-mixing reactions. Theta
emitters are glass tips containing an internal septum that separates two channels. When …

Droplet microfluidics for single‐molecule and single‐cell analysis in research, diagnosis, and therapy

SB Joel - Bulletin of the Korean Chemical Society, 2024 - kci.go.kr
During the last decade, molecular diagnostics has become increasingly important,
especially during the SARS‐CoV‐2 pandemic. Advances in droplet‐based microfluidics …

[PDF][PDF] Droplet-based microfluidics: formation, detection and analytical characterization

S Hassan, X Zhang, X Niu - Res. Dev. Mat. Sci, 2019 - m.milandmc.com
Microfluidics has become attractive in the recent decade due to its ability to offer low-cost,
robust and miniaturized assays at a small cost as compared to the bulk tests. The credit …

Droplet Microfluidics: Tools for Screening and Sorting Applications

DM Aubrecht - 2013 - dash.harvard.edu
Microfluidic droplets are a powerful tool for screening large populations of cells, molecules,
and biochemical reactions. Droplet systems are able to encapsulate, incubate, screen, and …

Microdroplet-assisted screening of biomolecule production for metabolic engineering applications

EK Bowman, HS Alper - Trends in biotechnology, 2020 - cell.com
Success in synthetic biology and metabolic engineering is quickly becoming 'test'limited
within the design–build–test cycle. Commonly used methods for high-throughput screening …

Analytical detection techniques for droplet microfluidics—A review

Y Zhu, Q Fang - Analytica chimica acta, 2013 - Elsevier
In the last decade, droplet-based microfluidics has undergone rapid progress in the fields of
single-cell analysis, digital PCR, protein crystallization and high throughput screening. It has …

Coupling liquid chromatography/mass spectrometry detection with microfluidic droplet array for label-free enzyme inhibition assay

XL Wang, Y Zhu, Q Fang - Analyst, 2014 - pubs.rsc.org
In this work, the combination of droplet-based microfluidics with liquid chromatography/mass
spectrometry (LC/MS) was achieved, for providing a fast separation and high-information …

Mass spectrometry-based high-throughput quantification of bioproducts in liquid culture

S Zhou, Z Fatma, P Xue, S Mishra, M Cao… - Analytical …, 2023 - ACS Publications
To meet the ever-increasing need for high-throughput screening in metabolic engineering,
information-rich, fast screening methods are needed. Mass spectrometry (MS) provides an …