The tumor microenvironment and its contribution to tumorigenesis has been a focal highlight
in recent years. A two-way communication between the tumor and the surrounding …

Hepatocellular carcinoma (HCC) is a primary liver tumor developing in the wake of chronic
liver disease. Chronic liver disease and inflammation leads to a fibrotic environment actively …

Hepatocellular carcinoma (HCC) is the fifth most common malignant cancer and the third
most frequent cause of tumour-related mortality worldwide. Currently, several surgical and …

Simple Summary The tumour microenvironment is composed of multiple non-cancerous
cells that communicate with the tumour cells, influencing their behaviour and impacting the …

In recent years, evidence has indicated that the tumor microenvironment (TME) plays a
significant role in tumor progression. Fibroblasts represent an abundant cell population in …

The tumor microenvironment contributes significantly to tumor initiation, progression, and
resistance to chemotherapy. Much of our understanding of the tumor and its …

Simple Summary Tumor stroma is known to significantly influence cancer initiation and
progression. In the last decade, 3D cell cultures have shown potential in modeling the tumor …

Preclinical models of cancer based on the use of human cancer cell lines and mouse
models have enabled discoveries that have been successfully translated into patients. And …

The hallmark of tumours is the ability of cancerous cells to promote vascular growth, to
disseminate and invade to distant organs. The metastatic process is heavily influenced by …

Abstract Three-dimensional (3D) cell cultures have emerged as valuable tools in cancer
research, offering significant advantages over traditional two-dimensional (2D) cell culture …