Recently, scientific interest in the brain–gut axis has grown dramatically, particularly with
respect to the link between gastrointestinal and psychiatric dysfunction. However, the role of …

Early-life adversity is a potent risk factor for mental-health disorders in exposed individuals,
and effects of adversity are exhibited across generations. Such adversities are also …

Early-life stress has pervasive, typically detrimental, effects on physical and mental health
across the lifespan. In rats, maternal-separation stress results in premature expression of an …

Rationale Intestinal permeability plays an important role in gut-brain axis communication.
Recent studies indicate that intestinal permeability increases in neonate pups during …

Early life stress (ELS) can affect brain development and increase lifetime prevalence of
psychiatric illnesses. However, the effective therapeutic interventions to ameliorate the …

Psychobiotics are considered among potential avenues for modulating the bidirectional
communication between the gastrointestinal tract and central nervous system, defined as the …

The developmental period constitutes a critical window of sensitivity to stress. Indeed, early-
life adversity increases the risk to develop psychiatric diseases, but also gastrointestinal …

Abstract Purpose of Review We review the state of the literature examining associations
between early life stress (ELS), gut microbiota, and neurocognitive development and mental …

Early life nutrition is critical for brain development. Dietary prebiotics and bioactive milk
fractions support brain development by increasing plasticity and altering activity in brain …

Early life is a period of significant brain development when the brain is at its most plastic and
vulnerable. Stressful episodes during this window of development have long-lasting effects …