Pre-clinical models of reward deficiency syndrome: A behavioral octopus
MC Gondré-Lewis, R Bassey, K Blum - Neuroscience & Biobehavioral …, 2020 - Elsevier
Individuals with mood disorders or with addiction, impulsivity and some personality
disorders can share in common a dysfunction in how the brain perceives reward, where …
disorders can share in common a dysfunction in how the brain perceives reward, where …
Reward deficiency syndrome (RDS) surprisingly is evolutionary and found everywhere: is it “blowin'in the wind”?
K Blum, T McLaughlin, A Bowirrat… - Journal of personalized …, 2022 - mdpi.com
Reward Deficiency Syndrome (RDS) encompasses many mental health disorders, including
a wide range of addictions and compulsive and impulsive behaviors. Described as an …
a wide range of addictions and compulsive and impulsive behaviors. Described as an …
Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings
This review summarizes evidence of dysregulated reward circuitry function in a range of
neurodevelopmental and psychiatric disorders and genetic syndromes. First, the …
neurodevelopmental and psychiatric disorders and genetic syndromes. First, the …
Should reward deficiency syndrome (RDS) be considered an umbrella disorder for mental illness and associated genetic and epigenetic induced dysregulation of …
K Blum, CA Dennen, I Elman, A Bowirrat… - Journal of Personalized …, 2022 - mdpi.com
Reward Deficiency Syndrome (RDS) is defined as a breakdown of reward
neurotransmission that results in a wide range of addictive, compulsive, and impulsive …
neurotransmission that results in a wide range of addictive, compulsive, and impulsive …
Clinically combating reward deficiency syndrome (RDS) with dopamine agonist therapy as a paradigm shift: dopamine for dinner?
Everyday, there are several millions of people that are increasingly unable to combat their
frustrating and even fatal romance with getting high and/or experiencing “normal” feelings of …
frustrating and even fatal romance with getting high and/or experiencing “normal” feelings of …
The neural circuitry of reward and its relevance to psychiatric disorders
DT Chau, RM Roth, AI Green - Current psychiatry reports, 2004 - Springer
Scientific interest in how the brain processes reward has burgeoned during the past 50
years since the discovery that rats will do tasks such as pressing a lever to obtain electrical …
years since the discovery that rats will do tasks such as pressing a lever to obtain electrical …
Activation instead of blocking mesolimbic dopaminergic reward circuitry is a preferred modality in the long term treatment of reward deficiency syndrome (RDS): a …
K Blum, ALC Chen, TJH Chen, ER Braverman… - Theoretical Biology and …, 2008 - Springer
Background and hypothesis Based on neurochemical and genetic evidence, we suggest
that both prevention and treatment of multiple addictions, such as dependence to alcohol …
that both prevention and treatment of multiple addictions, such as dependence to alcohol …
Translational assessment of reward and motivational deficits in psychiatric disorders
A Der-Avakian, SA Barnes, A Markou… - Translational …, 2016 - Springer
Deficits in reward and motivation are common symptoms characterizing several psychiatric
and neurological disorders. Such deficits may include anhedonia, defined as loss of …
and neurological disorders. Such deficits may include anhedonia, defined as loss of …
“Liking” and “wanting” linked to Reward Deficiency Syndrome (RDS): hypothesizing differential responsivity in brain reward circuitry
K Blum, E Gardner, M Oscar-Berman… - Current pharmaceutical …, 2012 - ingentaconnect.com
In an attempt to resolve controversy regarding the causal contributions of mesolimbic
dopamine (DA) systems to reward, we evaluate the three main competing explanatory …
dopamine (DA) systems to reward, we evaluate the three main competing explanatory …
Abnormal reward functioning across substance use disorders and major depressive disorder: Considering reward as a transdiagnostic mechanism
AR Baskin-Sommers, D Foti - International Journal of Psychophysiology, 2015 - Elsevier
A common criticism of the Diagnostic and Statistical Manual of Mental Disorders (American
Psychiatric Association, 2013) is that its criteria are based more on behavioral descriptions …
Psychiatric Association, 2013) is that its criteria are based more on behavioral descriptions …