Mononuclear phagocytes are an important component of an innate immune system
perceived as a system ready to react upon encounter of pathogens. Here, we show that in …

Tissue-infiltrating Ly6C hi monocytes play diverse roles in immunity, ranging from pathogen
killing to immune regulation. How and where this diversity of function is imposed remains …

Natural killer (NK) cells and dendritic cells (DCs) are recruited to inflammatory tissues in
response to infection. Following priming by pathogen-derived products, their reciprocal …

The cross-talk among cells of the innate immunity can greatly affect both innate and adaptive
responses. Here we analyzed the molecular interactions between human natural killer (NK) …

Animal models have highlighted the importance of innate lymphoid cells (ILCs) in multiple
immune responses. However, technical limitations have hampered adequate …

A reciprocal activating interaction between NK cells and dendritic cells (DC) has been
suggested to play a role in the functional regulation of these cells in immunity, but it has …

During innate immune responses, natural killer (NK) cells may interact with both
plasmacytoid dendritic cells (pDCs) and monocyte-derived dendritic cells (MDDCs). We …

The cross talk between NK cells and macrophages is emerging as a major line of defense
against microbial infections and tumors. This study reveals a complex network of soluble …

Innate lymphoid cells (ILCs) are positioned in tissues perinatally, constitutively express
receptors responsive to their organ microenvironments, and perform an arsenal of effector …

The perinatal period is a critical window for distribution of innate tissue-resident immune
cells within developing organs. Despite epidemiologic evidence implicating the early-life …