[HTML][HTML] Quick model-based viscoelastic clot strength predictions from blood protein concentrations for cybermedical coagulation control
DE Ghetmiri, AJ Venturi, MJ Cohen… - Nature …, 2024 - nature.com
Cybermedical systems that regulate patient clotting in real time with personalized blood
product delivery will improve treatment outcomes. These systems will harness popular …
product delivery will improve treatment outcomes. These systems will harness popular …
Control-theoretic modeling and prediction of blood clot viscoelasticity in trauma patients
DE Ghetmiri, MEP Blanco, MJ Cohen, AA Menezes - IFAC-PapersOnLine, 2021 - Elsevier
Current trauma-induced coagulopathy resuscitation protocols use large volumes of unchar-
acterized and non-tailored blood products, leading to 30% mortality. Blood coagulation after …
acterized and non-tailored blood products, leading to 30% mortality. Blood coagulation after …
Kinetic modeling of coagulation and fibrinolysis
R LeCover, T Orfeo, K Brummel-Ziedins, M Bravo… - IFAC-PapersOnLine, 2019 - Elsevier
Thromboelastic testing provides an assessment of a patient's coagulation and fibrinolytic
systems. In recent years, thromboelastic testing has become an important point of care …
systems. In recent years, thromboelastic testing has become an important point of care …
Leveraging turbidity and thromboelastography for complementary clot characterization
Thrombosis is a leading cause of death worldwide. Fibrin (ogen) is the protein primarily
responsible for clot formation or thrombosis. Therefore, characterizing fibrin clot formation is …
responsible for clot formation or thrombosis. Therefore, characterizing fibrin clot formation is …
[HTML][HTML] Personalized modulation of coagulation factors using a thrombin dynamics model to treat trauma-induced coagulopathy
DE Ghetmiri, MJ Cohen, AA Menezes - NPJ Systems Biology and …, 2021 - nature.com
Current trauma-induced coagulopathy resuscitation protocols use slow laboratory
measurements, rules-of-thumb, and clinician gestalt to administer large volumes of …
measurements, rules-of-thumb, and clinician gestalt to administer large volumes of …
Blood clot fracture properties are dependent on red blood cell and fibrin content
B Fereidoonnezhad, A Dwivedi, S Johnson… - Acta Biomaterialia, 2021 - Elsevier
Thrombus fragmentation during endovascular stroke treatment, such as mechanical
thrombectomy, leads to downstream emboli, resulting in poor clinical outcomes. Clinical …
thrombectomy, leads to downstream emboli, resulting in poor clinical outcomes. Clinical …
[PDF][PDF] Dynamic Modeling of Thromboelastography to inform state of coagulopathy in trauma patients
MA Pressly, MD Neal, G Clermont… - Foundations of Computer …, 2017 - folk.ntnu.no
Modeling clotting dynamics that occur during a thromboelastogram (TEG), a functional ex-
vivo assay of coagulation, has the potential to provide useful clinical insights. Taking a …
vivo assay of coagulation, has the potential to provide useful clinical insights. Taking a …
Basic principles of viscoelastic testing
T Carll, GD Wool - Transfusion, 2020 - Wiley Online Library
Background Viscoelastic testing is a method of hemostatic analysis that provides a real‐
time, holistic view of ex vivo clotting. It allows for examination of both cellular and plasma …
time, holistic view of ex vivo clotting. It allows for examination of both cellular and plasma …
Viscoelastic clot strength predicts coagulation-related mortality within 15 minutes
M Pezold, EE Moore, M Wohlauer, A Sauaia… - Surgery, 2012 - Elsevier
BACKGROUND: Predicting refractory coagulopathy early in resuscitation of injured patients
may decrease a leading cause of preventable death. We hypothesized that clot strength (G) …
may decrease a leading cause of preventable death. We hypothesized that clot strength (G) …
Assessing the methodology for calculating platelet contribution to clot strength (platelet component) in thromboelastometry and thrombelastography
C Solomon, M Ranucci, G Hochleitner… - Anesthesia & …, 2015 - journals.lww.com
The viscoelastic properties of blood clot have been studied most commonly using
thrombelastography (TEG®) and thromboelastometry (ROTEM®). ROTEM®-based bleeding …
thrombelastography (TEG®) and thromboelastometry (ROTEM®). ROTEM®-based bleeding …