Persistent abdominal pain is the most important reason for patients with irritable bowel
syndrome (IBS) to seek medical care. However, current therapies fail to adequately treat …

Evidence suggests that long-term stress facilitates visceral pain through sensitization of pain
pathways and promotes chronic visceral pain disorders such as the irritable bowel …

Background Women with a history of early life stress (ELS) have a higher risk of developing
irritable bowel syndrome (IBS). In addition, chronic stress in adulthood can exacerbate IBS …

Irritable bowel syndrome (IBS) is a brain-gut axis disorder characterized by abdominal pain
and altered bowel habits. IBS is a multifactorial, stress-sensitive disorder with evidence for …

Epigenetics is a process that alters gene activity or phenotype without any changes in the
underlying DNA sequence or genotype. These biological changes may have deleterious …

Chronic visceral pain represents a major unmet clinical need with the severity of pain
ranging from mild to so severe as to prevent individuals from participating in day-to-day …

Background Irritable bowel syndrome (IBS) and temporomandibular disorder (TMD) are two
chronic pain conditions that frequently overlap in the same individual, more commonly in …

Epigenetic molecular mechanisms, which include DNA methylation and histone
deacetylation, are implicated in the dysregulation of the hypothalamic-pituitary-adrenal …

Background & Aims Chronic stress alters the hypothalamic–pituitary–adrenal axis, increases
gut motility, and increases the perception of visceral pain. We investigated whether …

Visceral pain is generally poorly localized and characterized by hypersensitivity to a
stimulus such as organ distension. In concert with chronic visceral pain, there is a high …