[HTML][HTML] Binding of LAG-3 to stable peptide-MHC class II limits T cell function and suppresses autoimmunity and anti-cancer immunity
T Maruhashi, D Sugiura, I Okazaki, K Shimizu… - Immunity, 2022 - cell.com
Summary Lymphocyte activation gene-3 (LAG-3) is a potent inhibitory co-receptor; yet, its
functional ligand remains elusive, with distinct potential ligands identified. Here, we …
functional ligand remains elusive, with distinct potential ligands identified. Here, we …
[HTML][HTML] Fibrinogen-like protein 1 is a major immune inhibitory ligand of LAG-3
Summary Lymphocyte-activation gene 3 (LAG-3) is an immune inhibitory receptor, with
major histocompatibility complex class II (MHC-II) as a canonical ligand. However, it remains …
major histocompatibility complex class II (MHC-II) as a canonical ligand. However, it remains …
LAG-3 inhibits the activation of CD4+ T cells that recognize stable pMHCII through its conformation-dependent recognition of pMHCII
T Maruhashi, I Okazaki, D Sugiura, S Takahashi… - Nature …, 2018 - nature.com
The success of tumor immunotherapy targeting the inhibitory co-receptors PD-1 and CTLA-4
has indicated that many other co-receptors might be potential druggable targets, despite …
has indicated that many other co-receptors might be potential druggable targets, despite …
Atypical motifs in the cytoplasmic region of the inhibitory immune co-receptor LAG-3 inhibit T cell activation
TK Maeda, D Sugiura, I Okazaki, T Maruhashi… - Journal of Biological …, 2019 - ASBMB
T cell activation is tightly regulated by both stimulatory and inhibitory co-receptors and has
been a focus in the development of interventions for managing cancer or autoimmune …
been a focus in the development of interventions for managing cancer or autoimmune …
LAG3 associates with TCR–CD3 complexes and suppresses signaling by driving co-receptor–Lck dissociation
C Guy, DM Mitrea, PC Chou, J Temirov, KM Vignali… - Nature …, 2022 - nature.com
LAG3 is an inhibitory receptor that is highly expressed on exhausted T cells. Although LAG3-
targeting immunotherapeutics are currently in clinical trials, how LAG3 inhibits T cell function …
targeting immunotherapeutics are currently in clinical trials, how LAG3 inhibits T cell function …
LAG-3 regulates CD8+ T cell accumulation and effector function in murine self- and tumor-tolerance systems
JF Grosso, CC Kelleher, TJ Harris… - The Journal of …, 2007 - Am Soc Clin Investig
Lymphocyte activation gene-3 (LAG-3) is a cell-surface molecule with diverse biologic
effects on T cell function. We recently showed that LAG-3 signaling is important in CD4+ …
effects on T cell function. We recently showed that LAG-3 signaling is important in CD4+ …
LAG-3: a regulator of T-cell and DC responses and its use in therapeutic vaccination
F Triebel - Trends in immunology, 2003 - cell.com
The function mediated by the engagement of the lymphocyte activation gene-3 (LAG-3,
CD223) receptor expressed on activated T cells by its MHC class II ligand has remained …
CD223) receptor expressed on activated T cells by its MHC class II ligand has remained …
[HTML][HTML] LAG-3: from molecular functions to clinical applications
T Maruhashi, D Sugiura, I Okazaki… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
To prevent the destruction of tissues owing to excessive and/or inappropriate immune
responses, immune cells are under strict check by various regulatory mechanisms at …
responses, immune cells are under strict check by various regulatory mechanisms at …
The ligand-dependent suppression of TCR signaling by the immune checkpoint receptor LAG3 depends on the cytoplasmic RRFSALE motif
K Aigner-Radakovics, A De Sousa Linhares… - Science …, 2023 - science.org
Lymphocyte activation gene 3 (LAG3) is an inhibitory immune checkpoint receptor that
restrains autoimmune and antitumor responses, but its evolutionarily conserved cytoplasmic …
restrains autoimmune and antitumor responses, but its evolutionarily conserved cytoplasmic …
LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition
The immune checkpoint receptor lymphocyte activation gene 3 protein (LAG3) inhibits T cell
function upon binding to major histocompatibility complex class II (MHC class II) or …
function upon binding to major histocompatibility complex class II (MHC class II) or …