Background Primary lateral sclerosis (PLS) is traditionally regarded as a pure upper motor
neuron disorder, but recent cases series have highlighted cognitive deficits in executive and …

Background Primary lateral sclerosis (PLS) is traditionally solely associated with progressive
upper motor neuron dysfunction manifesting in limb spasticity, gait impairment, bulbar …

Advances in clinical care and recent research achievements: Primary lateral sclerosis (PLS)
has traditionally been regarded as a pure upper motor neuron condition, a view perpetuated …

Background Primary lateral sclerosis (PLS) is a low incidence motor neuron disease which
carries a markedly better prognosis than amyotrophic lateral sclerosis (ALS). Despite …

Background: Primary lateral sclerosis (PLS) is an idiopathic upper motor neuron
degenerative disorder. The aim of this study was to compare brain volumes in patients with …

Primary lateral sclerosis (PLS) is classically considered a 'pure'upper motor neuron disorder.
Motor cortex atrophy and pyramidal tract degeneration are thought to be pathognomonic of …

ObjectiveAdvanced neuroimaging techniques may offer the potential to monitor disease
progression in amyotrophic lateral sclerosis (ALS), a neurodegenerative, multisystem …

Background Primary lateral sclerosis is a progressive upper-motor-neuron disorder
associated with markedly longer survival than ALS. In contrast to ALS, the genetic …

Abstract Amyotrophic Lateral Sclerosis is a neurodegenerative disorder characterized
primarily by motor network disruption. Extra-motor manifestations including executive …

Objective To investigate the incidence and nature of language change and its relationship to
executive dysfunction in a population-based incident amyotrophic lateral sclerosis (ALS) …