Rheumatoid arthritis (RA), like many other autoimmune syndromes, is a disease of adults,
with the highest incidence rates reported in the elderly. The immune system undergoes …

Gain-of-function and loss-of-function in senescent T cells undermine protective immunity
and create the conditions for chronic tissue inflammation, a combination typically …

Immune aging is a complex process rendering the host susceptible to cancer, infection, and
insufficient tissue repair. Many autoimmune diseases preferentially occur during the second …

Current disease models of autoimmune syndromes, such as rheumatoid arthritis, propose
that chronic inflammation is caused by 'forbidden T-cell clones' that recognize disease …

The pathogenesis of rheumatoid arthritis (RA) is determined by a complex interaction of
genetic and environmental factors. Of all risk factors, age has the largest impact. RA occurs …

The aging process causes profound restructuring of the host immune system, typically
associated with declining host protection against cancer and infection. In the case of T cells …

Introduction The incidence of rheumatoid arthritis (RA) and its complications are expected to
increase with age. Remarkably, RA patients were identified features of accelerated aging …

Acquired immune function shows recognizable changes over time with organismal aging.
These changes include T-cell dysfunction, which may underlie diminished resistance to …

With increasing age, the ability of the immune system to protect against new antigenic
challenges or to control chronic infections erodes. Decline in thymic function and cumulating …

The adaptive immune system has the enormous challenge to protect the host through the
generation and differentiation of pathogen‐specific short‐lived effector T cells while in …