Comprehensive analysis of aflatoxin B1 biosynthesis in Aspergillus flavus via transcriptome-wide m6A methylome response to cycloleucine

L Liang, X Wang, H Lan, S Wei, Y Lei, S Zhang… - Journal of Hazardous …, 2024 - Elsevier
Aspergillus flavus and its toxic aflatoxins secondary metabolites contaminate food and
grains, posing a severe threat to human health and leading to liver cancer. Here, we …

Role of RNA Modifications, Especially m6A, in Aflatoxin Biosynthesis of Aspergillus flavus

C Yang, D Wu, H Lin, D Ma, W Fu, Y Yao… - Journal of Agricultural …, 2023 - ACS Publications
RNA modifications play key roles in eukaryotes, but the functions in Aspergillus flavus are
still unknown. Temperature has been reported previously to be a critical environmental …

m6A methyltransferase AflIme4 orchestrates mycelial growth, development and aflatoxin B1 biosynthesis in Aspergillus flavus

L Liang, X Wang, S Wei, Y Lei, S Zhang, H Zhai… - Microbiological …, 2024 - Elsevier
Abstract Aflatoxin B 1 (AFB 1), a highly toxic secondary metabolite produced by Aspergillus
flavus, poses a severe threat to agricultural production, food safety and human health. The …

Transcriptomic Insights into Benzenamine Effects on the Development, Aflatoxin Biosynthesis, and Virulence of Aspergillus flavus

M Yang, L Lu, S Li, J Zhang, Z Li, S Wu, Q Guo, H Liu… - Toxins, 2019 - mdpi.com
Aspergillus flavus is a soilborne pathogenic fungus that poses a serious public health threat
due to it contamination of food with carcinogenic aflatoxins. Our previous studies have …

Exploration of the Regulatory Mechanism of Secondary Metabolism by Comparative Transcriptomics in Aspergillus flavus

G Yao, Y Yue, Y Fu, Z Fang, Z Xu, G Ma… - Frontiers in …, 2018 - frontiersin.org
Mycotoxins cause a huge threaten to agriculture, food safety, and human and animal life.
Among them, aflatoxins (AFs) have always been considered the most potent carcinogens …

Suppression of Aflatoxin Biosynthesis in Aspergillus flavus by 2-Phenylethanol Is Associated with Stimulated Growth and Decreased Degradation of Branched-Chain …

PK Chang, SST Hua, SBL Sarreal, RW Li - Toxins, 2015 - mdpi.com
The saprophytic soil fungus Aspergillus flavus infects crops and produces aflatoxin. Pichia
anomala, which is a biocontrol yeast and produces the major volatile 2-phenylethanol (2 …

The epigenetic regulator Set9 harmonizes fungal development, secondary metabolism, and colonization capacity of Aspergillus flavus

L Hao, M Zhang, C Yang, X Pan, D Wu, H Lin… - International Journal of …, 2023 - Elsevier
As a widely distributed food-borne pathogenic fungus, Aspergillus flavus and its secondary
metabolites, mainly aflatoxin B1 (AFB 1), pose a great danger to humans. It is urgent to …

Integrated profiles of transcriptome and mRNA m6A modification reveal the intestinal cytotoxicity of aflatoxin B1 on HCT116 cells

Y Wu, W Bao, J Ren, C Li, M Chen, D Zhang, A Zhu - Genes, 2022 - mdpi.com
Aflatoxin B1 (AFB1) is widely prevalent in foods and animal feeds and is one of the most
toxic and carcinogenic aflatoxin subtypes. Existing studies have proved that the intestine is …

Transcriptomic responses of Aspergillus flavus to temperature and oxidative stresses during aflatoxin production

F Tian, SY Lee, SY Woo, HY Choi, S Heo, G Nah… - Scientific reports, 2021 - nature.com
Aflatoxin is a group of polyketide-derived carcinogenic and mutagenic secondary
metabolites produced by Aspergillus flavus that negatively impact global food security and …

Ethanol Inhibits Aflatoxin B1 Biosynthesis in Aspergillus flavus by Up-Regulating Oxidative Stress-Related Genes

Y Ren, J Jin, M Zheng, Q Yang, F Xing - Frontiers in Microbiology, 2020 - frontiersin.org
As the most carcinogenic, toxic, and economically costly mycotoxins, aflatoxin B1 (AFB1) is
primarily biosynthesized by Aspergillus flavus and Aspergillus parasiticus. Aflatoxin …