Conservation and variation in superantigen structure and activity highlighted by the three-dimensional structures of two new superantigens from Streptococcus …
Bacterial superantigens (SAgs) are a structurally related group of protein toxins secreted by
Staphylococcus aureus and Streptococcus pyogenes. They are implicated in a range of …
Staphylococcus aureus and Streptococcus pyogenes. They are implicated in a range of …
Crystallographic and mutational data show that the streptococcal pyrogenic exotoxin J can use a common binding surface for T-cell receptor binding and dimerization
The protein toxins known as superantigens (SAgs), which are expressed primarily by the
pathogenic bacteria Staphylococcus aureus and Streptococcus pyogenes, are highly potent …
pathogenic bacteria Staphylococcus aureus and Streptococcus pyogenes, are highly potent …
Crystal structure of the streptococcal superantigen SpeI and functional role of a novel loop domain in T cell activation by group V superantigens
JNP Brouillard, S Günther, AK Varma, I Gryski… - Journal of molecular …, 2007 - Elsevier
Superantigens (SAgs) are potent microbial toxins that bind simultaneously to T cell receptors
(TCRs) and class II major histocompatibility complex molecules, resulting in the activation …
(TCRs) and class II major histocompatibility complex molecules, resulting in the activation …
Crystal structure of staphylococcal enterotoxin G (SEG) in complex with a mouse T-cell receptor β chain
MM Fernández, S Cho, MC De Marzi, MC Kerzic… - Journal of Biological …, 2011 - ASBMB
Superantigens (SAgs) are bacterial or viral toxins that bind MHC class II (MHC-II) molecules
and T-cell receptor (TCR) in a nonconventional manner, inducing T-cell activation that leads …
and T-cell receptor (TCR) in a nonconventional manner, inducing T-cell activation that leads …
Superantigen natural affinity maturation revealed by the crystal structure of staphylococcal enterotoxin G and its binding to T‐cell receptor Vβ8. 2
MM Fernández, S Bhattacharya… - PROTEINS …, 2007 - Wiley Online Library
The illnesses associated with bacterial superantigens (SAgs) such as food poisoning and
toxic shock syndrome, as well as the emerging threat of purpura fulminans and community …
toxic shock syndrome, as well as the emerging threat of purpura fulminans and community …
[HTML][HTML] Streptococcal superantigens: biological properties and potential role in disease
Superantigens (SAgs) are a family of highly potent mitogens that share the ability to trigger
excessive stimulation of human and other mammalian T lymphocytes. This leads to a …
excessive stimulation of human and other mammalian T lymphocytes. This leads to a …
[HTML][HTML] Streptococcus pyogenes Superantigens: Biological properties and potential role in disease
T Proft, JD Fraser - … Basic Biology to Clinical Manifestations [Internet …, 2022 - ncbi.nlm.nih.gov
Superantigens (SAgs) are a family of highly potent mitogens that share the ability to trigger
excessive stimulation of human and other mammalian T lymphocytes. This leads to a …
excessive stimulation of human and other mammalian T lymphocytes. This leads to a …
A novel loop domain in superantigens extends their T cell receptor recognition site
Superantigens (SAGs) interact with host immune receptors to induce a massive release of
inflammatory cytokines that can lead to toxic shock syndrome and death. Bacterial SAGs can …
inflammatory cytokines that can lead to toxic shock syndrome and death. Bacterial SAGs can …
Structures of two streptococcal superantigens bound to TCR β chains reveal diversity in the architecture of T cell signaling complexes
Superantigens (SAGs) crosslink MHC class II and TCR molecules, resulting in an
overstimulation of T cells associated with human disease. SAGs interact with several …
overstimulation of T cells associated with human disease. SAGs interact with several …
Staphylococcal and streptococcal superantigens: molecular, biological and clinical aspects
JE Alouf, H Müller-Alouf - International journal of medical microbiology, 2003 - Elsevier
Superantigens (SAgs) include a class of certain bacterial and viral proteins exhibiting highly
potent lymphocyte-transforming (mitogenic) activity towards human and or other mammalian …
potent lymphocyte-transforming (mitogenic) activity towards human and or other mammalian …