The efficient delivery of therapeutic genes and appropriate gene expression are the crucial
issues for clinically relevant gene therapy. Viruses are naturally evolved vehicles which …

Gene therapy is now being applied to the treatment of a wide variety of acquired and
inherited diseases. One of the rate-limiting steps for successful gene therapy is the efficiency …

Viral vector is the most effective means of gene transfer to modify specific cell type or tissue
and can be manipulated to express therapeutic genes. Several virus types are currently …

After over 20years from the first application of gene transfer in humans, gene therapy is now
a mature discipline, which has progressively overcome several of the hurdles that prevented …

In the late 1970s, it was predicted that gene therapy would be applied to humans within a
decade. However, despite some success, gene therapy has still not become a routine …

Within the past decade, gene therapy strategies have come to the forefront of novel
therapeutics. Tremendous advances in vector technology along with deeper understandings …

No matter what their origin, strain and family, viruses have evolved exquisite strategies to
reach and penetrate specific target cells where they hijack the cellular machinery to express …

Considered by some to be among the simpler forms of life, viruses represent highly evolved
natural vectors for the transfer of foreign genetic information into cells. This attribute has led …

Gene therapy includes the application of various viral vectors, which represent most types
and families of viruses, suitable for infection of mammalian host cells. Both hereditary …

Although most research in the field of somatic gene therapy has investigated the use of
recombinant viruses for transferring genes into somatic target cells, various methods for …