Synthetic peptides corresponding to microbial epitopes stimulate T cell immunity but their
immunogenicity is poor and their half-lives are short. A viral epitope inserted into the …

Cytotoxic T lymphocytes (CTLs) recognize foreign peptides bound to major
histocompatibility complex (MHC) class I molecules. MHC molecules can also bind …

Low molecular weight material associated with affinity-purified class II major
histocompatibility complex (MHC) molecules of mouse (Ia) had the expected properties of …

Activated CD8+ T cells detect virally infected cells and tumor cells by recognition of major
histocompatibility complex class I–bound peptides derived from degraded, endogenously …

To provide a T-cell population that will respond promptly to foreign antigen, the immune
system looks inward, using the variety of self-antigens to select and maintain a diverse …

Contrary to previous predictions, relatively short synthetic peptides that mimic part of a
protein sequence are routinely capable of eliciting an antiserum that reacts with the partially …

Major histocompatibility complex (MHC) class II molecules can present peptides derived
from two different sources. The predominant source of peptide in uninfected antigen …

Targeting of antigens to antigen-presenting cells (APCs) increases CD4+ T cell activation,
and this observation can be exploited in the development of new vaccines. We have chosen …

Recombinant virus vaccines that express a limited number of epitopes are currently being
developed to prevent disease by changing the relative balance between viral spread and …

Recent advances in the preparation of synthetic peptide vaccines and the use of synthetic
peptides as probes of antigenic structure and function have led to renewed interest in the …