Metabolic acidosis is a common complication of chronic kidney disease; it is typically caused
by the accumulation of sulfate, phosphorus, and organic anions. Metabolic acidosis is …

Acid‐base equilibrium is a complex and vital system whose regulation is impaired in chronic
kidney disease (CKD). Metabolic acidosis is a common complication of CKD. It is typically …

Metabolic acidosis is a common complication associated with progressive loss of kidney
function. The diminishing ability of the kidneys to maintain acid–base homeostasis results in …

The optimal approach to managing acid-base balance is less well defined for patients
receiving hemodialysis than for those receiving peritoneal dialysis. Interventional studies in …

Chronic metabolic acidosis is common in dialysis patients. Bicarbonate administration via
the dialysate helps maintain the acid–base balance in these patients. Serum bicarbonate …

Metabolic acidosis is a common complication in chronic kidney disease (CKD) and end
stage renal disease (ESRD) and is known to be associated with deleterious outcomes under …

Rationale & Objective Excess morbidity and mortality are associated with both high and low
serum bicarbonate levels in epidemiologic studies of patients with end-stage kidney disease …

The use of high dialysate bicarbonate for hemodialysis in end-stage renal disease is
associated with increased mortality, but potential physiological mediators are poorly …

An optimal dialysate bicarbonate concentration is one that prevents postdialysis alkalemia
and predialysis acidosis. The bicarbonate requirements in any patient will depend on the …

During the last 20 years, concern about the acidbase status of patients receiving intermittent
hemodialysis (HD) has focused on potential problems and risks due to very low or very high …