Hemichannels, which are one half of the gap junction channels, have independent
physiological roles. Although hemichannels consisting of connexins are more widely …

Connexins and pannexins are vertebrate transmembrane proteins that form hexameric
conduits termed hemichannels. Functional hemichannels allow the diffusional transport of …

Hemichannels are large pore ion channels that in the traditional view are formed when half
a gap connexin junction opens to the extracellular space. It is now evident that other ion …

Mammals express∼ 20 different connexins, the main gap junction forming proteins in
mammals, and 3 pannexins, homologs of innexins, the main gap junction forming proteins in …

Gap junctions (GJ) and hemichannels (HC) formed from the protein subunits called
connexins are transmembrane conduits for the exchange of small molecules and ions …

Connexin hemichannels (connexons) are building blocks of gap junctions but also function
as free unapposed channels, which has become an active field of research. Defining …

Connexins and pannexins comprise two families of transmembrane proteins ubiquitously
distributed in vertebrates. Most cell types express more than 1 connexin or pannexin …

Functional interaction between neurons and glia is an exciting field that has expanded
tremendously during the past decade. Such partnership has multiple impacts on neuronal …

Cells of multicellular organisms need to communicate with each other and have evolved
various mechanisms for this purpose, the most direct and quickest of which is through …

The molecular identity of the protein forming “hemichannels” at non-junctional membranes is
disputed. The family of gap junction proteins, innexins, connexins, and pannexins share …