Roles of Grainyhead-like transcription factors in cancer

SM Frisch, JC Farris, PM Pifer - Oncogene, 2017 - nature.com
The mammalian homologs of the D. melanogaster Grainyhead gene, Grainyhead-like 1–3
(GRHL1, GRHL2 and GRHL3), are transcription factors implicated in wound healing …

Grainyhead-like 2 regulates epithelial plasticity and stemness in oral cancer cells

W Chen, JK Yi, T Shimane, S Mehrazarin… - …, 2016 - academic.oup.com
Abstract Grainyhead-like 2 (GRHL2) is one of the three mammalian homologues of
Drosophila Grainyhead involved in epithelial morphogenesis. We recently showed that …

Recent discoveries concerning the involvement of transcription factors from the Grainyhead-like family in cancer

M Mlacki, A Kikulska, E Krzywinska… - Experimental …, 2015 - journals.sagepub.com
The Grainyhead-like (GRHL) family of transcription factors has three mammalian members,
which are currently termed Grainyhead-like 1 (GRHL1), Grainyhead-like 2 (GRHL2), and …

[HTML][HTML] Grainyhead-like (Grhl) target genes in development and cancer

JG Gasperoni, JN Fuller, C Darido… - International Journal of …, 2022 - mdpi.com
Grainyhead-like (GRHL) factors are essential, highly conserved transcription factors (TFs)
that regulate processes common to both natural cellular behaviours during embryogenesis …

[HTML][HTML] Expression of transcription factor grainyhead-like 2 is diminished in cervical cancer

LA Torres-Reyes, L Alvarado-Ruiz… - … Journal of Clinical …, 2014 - ncbi.nlm.nih.gov
The transcription factor grainyhead-like 2 (GRHL2) is evolutionarily conserved in many
different species, and is involved in morphogenesis, epithelial differentiation, and the control …

Grainyhead-like transcription factors in cancer–Focus on recent developments

G Kotarba, A Taracha-Wisniewska… - Experimental …, 2020 - journals.sagepub.com
The role of grainyhead-like transcription factors in cancer has been widely investigated by
the scientific community. However, some of its aspects do not seem to be adequately …

Diverse expression patterns of the EMT suppressor grainyhead‐like 2 (GRHL 2) in normal and tumour tissues

S Riethdorf, S Frey, S Santjer… - … Journal of Cancer, 2016 - Wiley Online Library
The transcription factor grainyhead‐like 2 (GRHL2) plays a crucial role in various
developmental processes. Although GRHL2 recently has attracted considerable interest in …

Grainyhead-like protein 2: the emerging role in hormone-dependent cancers and epigenetics

RM Reese, MM Harrison, ET Alarid - Endocrinology, 2019 - academic.oup.com
In mammals, the grainyhead-like transcription factor (GRHL) family is composed of three
nuclear proteins that are responsible for driving epithelial cell fate: GRHL1, GRHL2, and …

[HTML][HTML] Spotlight on the granules (Grainyhead-like proteins)–from an evolutionary conserved controller of epithelial trait to pioneering the chromatin landscape

V Sundararajan, QY Pang, M Choolani… - Frontiers in Molecular …, 2020 - frontiersin.org
Among the transcription factors that are conserved across phylogeny, the grainyhead family
holds vital roles in driving the epithelial cell fate. In Drosophila, the function of grainyhead …

[HTML][HTML] Dual roles of the transcription factor grainyhead-like 2 (GRHL2) in breast cancer

S Werner, S Frey, S Riethdorf, C Schulze… - Journal of biological …, 2013 - ASBMB
Using a retrovirus-mediated cDNA expression cloning approach, we identified the
grainyhead-like 2 (GRHL2) transcription factor as novel protooncogene. Overexpression of …