Effects of insufficient sleep on circadian rhythmicity and expression amplitude of the human blood transcriptome
Insufficient sleep and circadian rhythm disruption are associated with negative health
outcomes, including obesity, cardiovascular disease, and cognitive impairment, but the …
outcomes, including obesity, cardiovascular disease, and cognitive impairment, but the …
How sleep and wakefulness influence circadian rhythmicity: effects of insufficient and mistimed sleep on the animal and human transcriptome
The mammalian circadian system is a multi‐oscillator, hierarchically organised system
where a central pacemaker synchronises behavioural, physiological and gene expression …
where a central pacemaker synchronises behavioural, physiological and gene expression …
Blood-gene expression reveals reduced circadian rhythmicity in individuals resistant to sleep deprivation
ES Arnardottir, EV Nikonova, KR Shockley… - Sleep, 2014 - academic.oup.com
Abstract Study Objectives: To address whether changes in gene expression in blood cells
with sleep loss are different in individuals resistant and sensitive to sleep deprivation …
with sleep loss are different in individuals resistant and sensitive to sleep deprivation …
Simulated night shift work induces circadian misalignment of the human peripheral blood mononuclear cell transcriptome
L Kervezee, M Cuesta… - Proceedings of the …, 2018 - National Acad Sciences
Misalignment of the endogenous circadian timing system leads to disruption of physiological
rhythms and may contribute to the development of the deleterious health effects associated …
rhythms and may contribute to the development of the deleterious health effects associated …
Partial sleep restriction activates immune response-related gene expression pathways: experimental and epidemiological studies in humans
V Aho, HM Ollila, V Rantanen, E Kronholm, I Surakka… - PloS one, 2013 - journals.plos.org
Epidemiological studies have shown that short or insufficient sleep is associated with
increased risk for metabolic diseases and mortality. To elucidate mechanisms behind this …
increased risk for metabolic diseases and mortality. To elucidate mechanisms behind this …
Mistimed sleep disrupts circadian regulation of the human transcriptome
Circadian organization of the mammalian transcriptome is achieved by rhythmic recruitment
of key modifiers of chromatin structure and transcriptional and translational processes …
of key modifiers of chromatin structure and transcriptional and translational processes …
Circadian Clock Genes Per1 and Per2 Regulate the Response of Metabolism-Associated Transcripts to Sleep Disruption
Human and animal studies demonstrate that short sleep or poor sleep quality, eg in night
shift workers, promote the development of obesity and diabetes. Effects of sleep disruption …
shift workers, promote the development of obesity and diabetes. Effects of sleep disruption …
Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses
V Aho, HM Ollila, E Kronholm, I Bondia-Pons… - Scientific reports, 2016 - nature.com
Sleep loss and insufficient sleep are risk factors for cardiometabolic diseases, but data on
how insufficient sleep contributes to these diseases are scarce. These questions were …
how insufficient sleep contributes to these diseases are scarce. These questions were …
Acute sleep loss induces tissue-specific epigenetic and transcriptional alterations to circadian clock genes in men
J Cedernaes, ME Osler, S Voisin… - The Journal of …, 2015 - academic.oup.com
Context: Shift workers are at increased risk of metabolic morbidities. Clock genes are known
to regulate metabolic processes in peripheral tissues, eg, glucose oxidation. Objective: This …
to regulate metabolic processes in peripheral tissues, eg, glucose oxidation. Objective: This …
Adverse metabolic consequences in humans of prolonged sleep restriction combined with circadian disruption
Epidemiological studies link short sleep duration and circadian disruption with higher risk of
metabolic syndrome and diabetes. We tested the hypotheses that prolonged sleep …
metabolic syndrome and diabetes. We tested the hypotheses that prolonged sleep …
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