Insufficient sleep and circadian rhythm disruption are associated with negative health
outcomes, including obesity, cardiovascular disease, and cognitive impairment, but the …

The mammalian circadian system is a multi‐oscillator, hierarchically organised system
where a central pacemaker synchronises behavioural, physiological and gene expression …

Abstract Study Objectives: To address whether changes in gene expression in blood cells
with sleep loss are different in individuals resistant and sensitive to sleep deprivation …

Misalignment of the endogenous circadian timing system leads to disruption of physiological
rhythms and may contribute to the development of the deleterious health effects associated …

Epidemiological studies have shown that short or insufficient sleep is associated with
increased risk for metabolic diseases and mortality. To elucidate mechanisms behind this …

Circadian organization of the mammalian transcriptome is achieved by rhythmic recruitment
of key modifiers of chromatin structure and transcriptional and translational processes …

Human and animal studies demonstrate that short sleep or poor sleep quality, eg in night
shift workers, promote the development of obesity and diabetes. Effects of sleep disruption …

Sleep loss and insufficient sleep are risk factors for cardiometabolic diseases, but data on
how insufficient sleep contributes to these diseases are scarce. These questions were …

Context: Shift workers are at increased risk of metabolic morbidities. Clock genes are known
to regulate metabolic processes in peripheral tissues, eg, glucose oxidation. Objective: This …

Epidemiological studies link short sleep duration and circadian disruption with higher risk of
metabolic syndrome and diabetes. We tested the hypotheses that prolonged sleep …