Weighing the evidence for pharmacological treatment interventions in mild COPD; a narrative perspective

D Singh, AD D'Urzo, JF Donohue, EM Kerwin - Respiratory research, 2019 - Springer
There is increasing focus on understanding the nature of chronic obstructive pulmonary
disease (COPD) during the earlier stages. Mild COPD (Global Initiative for Chronic …

Rationale for earlier treatment in COPD: a systematic review of published literature in mild-to-moderate COPD

F Maltais, N Dennis, CKN Chan - COPD: Journal of Chronic …, 2013 - Taylor & Francis
COPD is progressive and typically begins many years before a definite diagnosis is made.
As the rate of decline in lung function may be faster in the initial stages of the disease, early …

Should mild COPD be treated? Evidence for early pharmacological intervention

AF Elbehairy, KA Webb, J Alberto Neder, DE O'Donnell - Drugs, 2013 - Springer
Chronic obstructive pulmonary disease (COPD) is a common and often progressive
inflammatory disease of the airways that is both preventable and treatable. It is well …

What have we learned from observational studies and clinical trials of mild to moderate COPD?

M Barrecheguren, C González, M Miravitlles - Respiratory research, 2018 - Springer
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality
worldwide. It is well established that patients with mild to moderate disease represent the …

[HTML][HTML] Maintenance pharmacotherapy of mild and moderate COPD: what is the evidence?

GT Ferguson - Respiratory medicine, 2011 - Elsevier
Chronic obstructive pulmonary disease (COPD) affects more than 24 million individuals in
the United States, although at least half of the cases are not diagnosed. Proactive diagnosis …

COPD: early diagnosis and treatment to slow disease progression

T Welte, C Vogelmeier, A Papi - International journal of clinical …, 2015 - Wiley Online Library
Aims Chronic obstructive pulmonary disease (COPD) is usually a progressive condition.
Undiagnosed early‐stage disease, particularly in symptomatic patients, is likely to become …

[HTML][HTML] New horizons in early stage COPD–improving knowledge, detection and treatment

M Decramer, M Miravitlles, D Price… - Respiratory …, 2011 - Elsevier
Early stage COPD carries a significant healthcare burden that is currently underrecognised,
underdiagnosed and undertreated. Furthermore, patients at this stage can rapidly decline to …

Optimizing management of chronic obstructive pulmonary disease in the upcoming decade

R Russell, A Anzueto, I Weisman - International Journal of Chronic …, 2011 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD) is a leading cause of disability and mortality.
Caring for patients with COPD, particularly those with advanced disease who experience …

The role of pharmacotherapy in mild to moderate chronic obstructive pulmonary disease

N Raghavan, JA Guenette… - … in Respiratory Disease, 2011 - journals.sagepub.com
Chronic obstructive pulmonary disease (COPD) is a major health problem worldwide and
most of those afflicted have mild to moderate disease as measured by spirometry. There is …

An overview of the current management of chronic obstructive pulmonary disease: can we go beyond the GOLD recommendations?

M Cazzola, P Rogliani, E Puxeddu, J Ora… - Expert review of …, 2018 - Taylor & Francis
Introduction: Treatment recommendations are based on randomized controlled trials (RCTs).
However, only about 1 in 20 people meet the inclusion criteria for RCTs forming consensus …