Achieving continuous manufacturing: Technologies and approaches for synthesis, workup, and isolation of drug substance. May 20–21, 2014 Continuous …

IR Baxendale, RD Braatz, BK Hodnett… - Journal of …, 2015 - Wiley Online Library
This whitepaper highlights current challenges and opportunities associated with continuous
synthesis, workup, and crystallization of active pharmaceutical ingredients (drug …

Continuous manufacturing in pharmaceutical process development and manufacturing

CL Burcham, AJ Florence… - Annual review of …, 2018 - annualreviews.org
The pharmaceutical industry has found new applications for the use of continuous
processing for the manufacture of new therapies currently in development. The …

[图书][B] Continuous manufacturing of pharmaceuticals

P Kleinebudde, J Khinast, J Rantanen - 2017 - books.google.com
A comprehensive look at existing technologies and processes for continuous manufacturing
of pharmaceuticals As rising costs outpace new drug development, the pharmaceutical …

Continuous flow technology vs. the batch-by-batch approach to produce pharmaceutical compounds

KP Cole, MD Johnson - Expert review of clinical pharmacology, 2018 - Taylor & Francis
Introduction: For the manufacture of small molecule drugs, many pharmaceutical innovator
companies have recently invested in continuous processing, which can offer significant …

Achieving continuous manufacturing May 20–21 2014 continuous manufacturing symposium

C Badman, BL Trout - Journal of pharmaceutical sciences, 2015 - jpharmsci.org
The white papers presented here are a remarkable collection of work, unified by the goal of
building upon the in-roads that continuous manufacturing has made in the pharmaceutical …

Continuous processing in the manufacture of active pharmaceutical ingredients and finished dosage forms: an industry perspective

P Poechlauer, J Manley, R Broxterman… - … Process Research & …, 2012 - ACS Publications
Continuous manufacturing as a way of producing fine chemicals, active pharmaceutical
ingredients, and finished dosage forms is gaining widespread attention. Although potential …

Integrated continuous pharmaceutical technologies—a review

A Domokos, B Nagy, B Szilagyi, G Marosi… - … Process Research & …, 2021 - ACS Publications
Innovation in the pharmaceutical industry has been limited for a long time to the research
and development of new active compounds; meanwhile, the structure of the production …

Achieving continuous manufacturing for final dosage formation: challenges and how to meet them. May 20–21, 2014 continuous manufacturing symposium

S Byrn, M Futran, H Thomas, E Jayjock… - Journal of …, 2015 - Wiley Online Library
We describe the key issues and possibilities for continuous final dosage formation,
otherwise known as downstream processing or drug product manufacturing. A distinction is …

Regulatory perspectives on continuous pharmaceutical manufacturing: moving from theory to practice: September 26-27, 2016, international symposium on the …

MM Nasr, M Krumme, Y Matsuda, BL Trout… - Journal of …, 2017 - Elsevier
Continuous manufacturing plays a key role in enabling the modernization of pharmaceutical
manufacturing. The fate of this emerging technology will rely, in large part, on the regulatory …

Progress to date in the design and operation of continuous crystallization processes for pharmaceutical applications

B Wood, KP Girard, CS Polster… - … Process Research & …, 2019 - ACS Publications
Continuous crystallization has gained interest in the pharmaceutical sector as part of the
drive toward the transition from exclusive batch manufacturing to integrated continuous …