Atorvastatin has been shown to reduce early brain edema and neuronal death after
subarachnoid hemorrhage, but its mechanism is not clear. In this study, rat models of …

Backgroud Cerebral vasospasm (CVS) and early brain injury remain major causes of
morbidity and mortality after aneurysmal subarachnoid hemorrhage (SAH) …

Object. Atorvastatin, a β-hydroxy-β-methylglutaryl coenzyme A reductase inhibitor, improves
neurological functional outcome, reduces cerebral cell loss, and promotes regional cellular …

Aneurysmal subarachnoid hemorrhage (SAH) is a severe cerebrovascular disease with very
poor prognosis. The aim of the present study was to evaluate the protective effects of …

Atorvastatin, a lipid-lowering medication, provides neuroprotective effects, although the
precise mechanisms of action remain unclear. Our previous studies confirmed activated …

Object. Atorvastatin, a β-hydroxy-β-methylglutaryl coenzyme A reductase inhibitor, has
pleiotropic effects such as improving thrombogenic profile, promoting angiogenesis, and …

We evaluated the neuroprotective effects of atorvastatin (2, 5, and 10 mg/kg) on
experimentally induced intracerebral hemorrhage (ICH) in adult rats; controls were …

The treatment of traumatic brain injury (TBI) remains limited, and aside from surgical
hematoma evacuation, clinical management is largely supportive and directed toward …

Subarachnoid hemorrhage (SAH) is a subtype of stroke with high mortality and morbidity
due to the lack of effective therapy. Atorvastatin has been reported to alleviate early brain …

Background Statins, or 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, have
been suggested to possess pleiotropic effects, including antioxidant and anti-inflammatory …