Abstract Cytosine-phosphate-guanine (CpG) DNA is known to increase the potency of
vaccines. Here, in vitro and in vivo stimulation of toll-like receptor 9 by CpG DNA …

Investigation of mouse macrophage-like RAW264. 7 cells showed that the
immunostimulatory activity of CpG DNA is increased by formation of polypod-like structured …

Nanosized DNA assemblies are useful for delivering immunostimulatory cytosine–
phosphate–guanine (CpG) DNA to immune cells, but little is known about the optimal …

It was previously demonstrated that polypod‐like nanostructured DNA (polypodna)
comprising three or more oligodeoxynucleotides (ODNs) were useful for the delivery of …

Purpose We previously demonstrated that the immunostimulatory activity of CpG DNA is
increased by the formation of polypod-like structures. The present study was designed to …

DNA containing unmethylated deoxycytidylyl-deoxyguanosine (CpG) dinucleotides (CpG
DNA) is a potent stimulator of immune responses through triggering of Toll-like receptor 9 …

A151 and other immunosuppressive oligodeoxynucleotides that act as Toll-like receptor
(TLR) 9 antagonists are candidate agents for the treatment of autoimmune and inflammatory …

Oligodeoxynucleotide (ODN) containing a cytosine-phosphate-guanine (CpG) motif, or CpG
ODN, is considered suitable for treating immune diseases, including allergies. Although the …

CpG oligodeoxynucleotides (CpG ODNs) bind to toll-like receptor 9 (TLR9) and activate the
immune system. Thus, CpG ODNs have attracted considerable interest as …

Polypod-like structured nucleic acids (polypodnas), which are nanostructured DNAs, are
useful for delivering cytosine-phosphate guanine oligodeoxynucleotides (CpG ODNs) to …