Background The transient middle cerebral artery occlusion (tMCAO) model is used for
studying the molecular mechanisms of ischemic damage and neuroprotection. Numerous …

With increasing distribution of endovascular stroke therapies, transient middle cerebral
artery occlusion (tMCAO) in mice now more than ever depicts a relevant patient population …

Ischemic stroke (IS) is a detrimental neurological disease with limited treatments options. It
has been challenging to define the roles of brain cell subsets in IS onset and progression …

To gain greater insight on the molecular mechanisms that underlie ischemic stroke, we
compared gene expression profiles in transient (tMCAO) and permanent middle cerebral …

Brain ischemia, also termed cerebral ischemia, is a condition in which there is insufficient
blood flow to the brain to meet metabolic demand, leading to tissue death (cerebral …

Background A large number of genes are regulated to promote brain repair following stroke.
The thorough analysis of this process can help identify new markers and develop …

Stroke is a leading cause of death worldwide and continues to be one of the major causes of
long-term adult disabilities. About 87% of strokes are ischemic in origin and occur in the …

Ischemic stroke, which accounts for 87% of all strokes, constitutes the leading cause of
morbidity and mortality in China. Although the genetics and epigenetics of stroke have been …

Background Altered gene expression is an important feature of ischemic cerebral injury and
affects proteins of many functional classes. We have used microarrays to investigate the …

Cerebrovascular disease is highly prevalent in the global population and encompasses
several types of conditions, including stroke. To study the impact of stroke on tissue injury …