Background Senescent cells, which can release factors that cause inflammation and
dysfunction, the senescence-associated secretory phenotype (SASP), accumulate with …

Cellular senescence and the hallmarks of aging contribute to age-related disease and
dysfunction. The Unitary Theory of Fundamental Aging Mechanisms highlights the …

Cellular senescence (CS) is increasingly implicated in the etiology of age-related diseases.
While CS can facilitate physiological processes such as tissue repair and wound healing …

Senolytics are a class of drugs that selectively clear senescent cells (SC). The first senolytic
drugs Dasatinib, Quercetin, Fisetin and Navitoclax were discovered using a hypothesis …

Physical function declines in old age, portending disability, increased health expenditures,
and mortality. Cellular senescence, leading to tissue dysfunction, may contribute to these …

Aging results in an elevated burden of senescent cells, senescence‐associated secretory
phenotype (SASP), and tissue infiltration of immune cells contributing to chronic low‐grade …

The increasing life expectancy of the world population has become an economic and global
public health problem. Increased life expectancy tracks with a higher incidence of multiple …

Background Cellular senescence is a key mechanism that drives age-related diseases, but
has yet to be targeted therapeutically in humans. Idiopathic pulmonary fibrosis (IPF) is a …

The healthspan of mice is enhanced by killing senescent cells using a transgenic suicide
gene. Achieving the same using small molecules would have a tremendous impact on …

Cellular senescence is a ubiquitous process with roles in tissue remodelling, including
wound repair and embryogenesis. However, prolonged senescence can be maladaptive …