Continuous cell division is a hallmark of cancer and cell-cycle regulators therefore represent
relevant target molecules for tumor therapy. Among these targets the cyclins are of particular …

Uncontrolled cell division is an indispensable event in tumor progression, and numerous
molecules involved in this process have been the focus of intense investigation in tumor …

Cyclin B1, which plays a key role in the control of cell cycle progression from G2 through M
phase, was recently identified by us as a tumor antigen recognized by human T-cells. To …

Purpose: Cyclin B1–derived peptides were shown by us to be targets of tumor-specific CD8+
T cells in patients with breast and head and neck cancer. We obtained further evidence of …

We previously identified the aberrantly expressed cell cycle regulator cyclin B1 as a tumor
antigen recognized by antibodies and T cells from patients with breast, lung, and head and …

Cyclin B1 is a checkpoint protein that regulates cell division from G2 to the M phase. Studies
in mice have shown that cyclin B1 vaccine-induced immunity significantly delayed or …

Purpose: Cyclin D1, a key cell cycle regulator, is overexpressed in multiple types of cancer.
Such tumor-associated genes may be useful targets for cancer immunotherapy …

Cyclin‐A2, a key cell cycle regulator, has been shown to be overexpressed in various types
of malignancies with little expression in normal tissue. Such tumor‐associated genes …

Antibodies, especially monoclonal antibodies, are highly specific for their target antigens
and have found extensive clinical application in the treatment of infectious diseases and …

Cyclins are indispensable elements of the cell cycle and derangement of their function can
lead to cancer formation. Recent studies have also revealed more mechanisms through …