Motor neuronal protection by L-arginine prolongs survival of mutant SOD1 (G93A) ALS mice
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by
progressive paralysis due to motor neuron degeneration. Despite the fact that many different …
progressive paralysis due to motor neuron degeneration. Despite the fact that many different …
Differential regulation of neuronal and inducible nitric oxide synthase (NOS) in the spinal cord of mutant SOD1 (G93A) ALS mice
Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder characterized by
degeneration of motor neurons throughout the central nervous system. Mutations of the free …
degeneration of motor neurons throughout the central nervous system. Mutations of the free …
d‐Serine is a key determinant of glutamate toxicity in amyotrophic lateral sclerosis
Excitotoxicity has been implicated in the pathogenesis of amyotrophic lateral sclerosis
(ALS). More recently, glial involvement has been shown to be essential for ALS‐related …
(ALS). More recently, glial involvement has been shown to be essential for ALS‐related …
Intrathecal Delivery of ssAAV9-DAO Extends Survival in SOD1G93A ALS Mice
W Wang, W Duan, Y Wang, D Wen, Y Liu, Z Li… - Neurochemical …, 2017 - Springer
Amyotrophic lateral sclerosis (ALS) is an adult-onset, irreversible neurodegenerative
disease that leads to progressive paralysis and inevitable death 3–5 years after diagnosis …
disease that leads to progressive paralysis and inevitable death 3–5 years after diagnosis …
N-acetyl-L-tryptophan delays disease onset and extends survival in an amyotrophic lateral sclerosis transgenic mouse model
Background Whether l-NAT, a cytochrome c release inhibitor and an antagonist of NK-1R,
provides protection in ALS is not known. Results l-NAT delays disease onset and mortality in …
provides protection in ALS is not known. Results l-NAT delays disease onset and mortality in …
Differences of transport activity of arginine and regulation on neuronal nitric oxide synthase and oxidative stress in amyotrophic lateral sclerosis model cell lines
S Latif, YS Kang - Cells, 2021 - mdpi.com
L-Arginine, a semi-essential amino acid, was shown to delay dysfunction of motor neurons
and to prolong the lifespan, upon analysis of transgenic mouse models of amyotrophic …
and to prolong the lifespan, upon analysis of transgenic mouse models of amyotrophic …
d-Amino acid oxidase controls motoneuron degeneration through d-serine
J Sasabe, Y Miyoshi, M Suzuki, M Mita… - Proceedings of the …, 2012 - National Acad Sciences
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder involving an
extensive loss of motoneurons. Aberrant excitability of motoneurons has been implicated in …
extensive loss of motoneurons. Aberrant excitability of motoneurons has been implicated in …
Focus on the role of d-serine and d-amino acid oxidase in amyotrophic lateral sclerosis/motor neuron disease (ALS)
NR Kondori, P Paul, JP Robbins, K Liu… - Frontiers in molecular …, 2018 - frontiersin.org
We have investigated a pathogenic mutation in D-amino acid oxidase (DAO), DAOR199W,
associated with familial Amyotrophic Lateral Sclerosis (ALS) that impairs D-serine …
associated with familial Amyotrophic Lateral Sclerosis (ALS) that impairs D-serine …
[HTML][HTML] Knocking down metabotropic glutamate receptor 1 improves survival and disease progression in the SOD1G93A mouse model of amyotrophic lateral …
M Milanese, F Giribaldi, M Melone, T Bonifacino… - Neurobiology of …, 2014 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a late-onset fatal neurodegenerative disease
reflecting degeneration of upper and lower motoneurons (MNs). The cause of ALS and the …
reflecting degeneration of upper and lower motoneurons (MNs). The cause of ALS and the …
ROCK inhibition improves axonal regeneration in a preclinical model of amyotrophic lateral sclerosis
AR Joshi, I Muke, I Bobylev… - Journal of Comparative …, 2019 - Wiley Online Library
Alteration of the RhoA/ROCK (Rho kinase) pathway has been shown to be neuroprotective
in SOD1G93A mice, the most commonly used animal model of ALS. Since previous studies …
in SOD1G93A mice, the most commonly used animal model of ALS. Since previous studies …