Sulforaphane as a potential protective phytochemical against neurodegenerative diseases

A Tarozzi, C Angeloni, M Malaguti… - Oxidative medicine …, 2013 - Wiley Online Library
A wide variety of acute and chronic neurodegenerative diseases, including
ischemic/traumatic brain injury, Alzheimer's disease, and Parkinson′ s disease, share …

Efficacy of sulforaphane in neurodegenerative diseases

G Schepici, P Bramanti, E Mazzon - International journal of molecular …, 2020 - mdpi.com
Sulforaphane (SFN) is a phytocompound belonging to the isothiocyanate family. Although it
was also found in seeds and mature plants, SFN is mainly present in sprouts of many …

Effects of sulforaphane in the central nervous system

C Huang, J Wu, D Chen, J Jin, Y Wu, Z Chen - European journal of …, 2019 - Elsevier
Sulforaphane (SFN) is an active component extracted from vegetables like cauliflower and
broccoli. Activation of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) signaling is a …

Sulforaphane-role in aging and neurodegeneration

R Santín-Márquez, A Alarcón-Aguilar… - Geroscience, 2019 - Springer
In the last several years, numerous molecules derived from plants and vegetables have
been tested for their antioxidant, anti-inflammatory, and anti-aging properties. One of them is …

The neuroprotective mechanisms and effects of sulforaphane

EA Klomparens, Y Ding - Brain Circulation, 2019 - journals.lww.com
Sulforaphane (SFN) is a phytochemical found in cruciferous vegetables. It has been shown
to have many protective effects against many diseases, including multiple types of cancer …

Pre-clinical neuroprotective evidences and plausible mechanisms of Sulforaphane in Alzheimer's disease

J Kim - International journal of molecular sciences, 2021 - mdpi.com
Sulforaphane, a potent dietary bioactive agent obtainable from cruciferous vegetables, has
been extensively studied for its effects in disease prevention and therapy. Sulforaphane …

Emerging promise of sulforaphane-mediated Nrf2 signaling cascade against neurological disorders

MS Uddin, A Al Mamun, M Jakaria… - Science of the Total …, 2020 - Elsevier
Neurological disorders represent a great challenge and are the leading cause of death and
disability globally. Although numerous complicated mechanisms are involved in the …

Sulforaphane protects against rotenone-induced neurotoxicity in vivo: Involvement of the mTOR, Nrf2 and autophagy pathways

Q Zhou, B Chen, X Wang, L Wu, Y Yang, X Cheng… - Scientific reports, 2016 - nature.com
Sulforaphane, a naturally occurring compound found in cruciferous vegetables, has been
shown to be neuroprotective in several neurological disorders. In this study, we sought to …

Amelioration of Alzheimer's disease by neuroprotective effect of sulforaphane in animal model

HV Kim, HY Kim, HY Ehrlich, SY Choi, DJ Kim, YS Kim - Amyloid, 2013 - Taylor & Francis
Pathophysiological evidences of AD have indicated that aggregation of Aβ is one of the
principal causes of neuronal dysfunction, largely by way of inducing oxidative stresses such …

An overview on neuroprotective effects of isothiocyanates for the treatment of neurodegenerative diseases

S Giacoppo, M Galuppo, S Montaut, R Iori, P Rollin… - Fitoterapia, 2015 - Elsevier
The discovery of new natural compounds with pharmacological properties is a field of
interest widely growing, especially for the management of neurodegenerative diseases. As …