Cannabidiol‐rich non‐psychotropic Cannabis sativa L. oils attenuate peripheral neuropathy symptoms by regulation of CB2‐mediated microglial neuroinflammation

V Borgonetti, L Anceschi, V Brighenti… - Phytotherapy …, 2023 - Wiley Online Library
Neuropathic pain (NP) is a chronic disease that affects the normal quality of life of patients.
To date, the therapies available are only symptomatic and they are unable to reduce the …

Non‐psychotropic Cannabis sativa L. phytocomplex modulates microglial inflammatory response through CB2 receptors‐, endocannabinoids‐, and NF‐κB‐mediated …

V Borgonetti, C Benatti, P Governa… - Phytotherapy …, 2022 - Wiley Online Library
Cannabis sativa L. is increasingly emerging for its protective role in modulating
neuroinflammation, a complex process orchestrated among others by microglia, the resident …

Combined non-psychoactive Cannabis components cannabidiol and β-caryophyllene reduce chronic pain via CB1 interaction in a rat spinal cord injury model

A Eeswara, A Pacheco-Spiewak, S Jergova, J Sagen - PloS one, 2023 - journals.plos.org
The most frequently reported use of medical marijuana is for pain relief. However, its
psychoactive component Δ9-tetrahydrocannabinol (THC) causes significant side effects …

The anti-inflammatory and analgesic effects of formulated full-spectrum cannabis extract in the treatment of neuropathic pain associated with multiple sclerosis

ZH Maayah, S Takahara, M Ferdaoussi… - Inflammation …, 2020 - Springer
Purpose Cannabis has been used for thousands of years in many cultures for the treatment
of several ailments including pain. The benefits of cannabis are mediated largely by …

Combinations of Cannabidiol and Δ9-Tetrahydrocannabinol in Reducing Chemotherapeutic Induced Neuropathic Pain

DE Sepulveda, KE Vrana, NM Graziane… - Biomedicines, 2022 - mdpi.com
Neuropathic pain is a condition that impacts a substantial portion of the population and is
expected to affect a larger percentage in the future. This type of pain is poorly managed by …

Plant-based cannabinoids for the treatment of chronic neuropathic pain

SL Casey, CW Vaughan - Medicines, 2018 - mdpi.com
Chronic neuropathic pain is a prevalent condition that places a heavy burden on individuals
and the healthcare system. Current medications have limitations and new approaches are …

The non-psychoactive plant cannabinoid, cannabidiol affects cholesterol metabolism-related genes in microglial cells

N Rimmerman, A Juknat, E Kozela, R Levy… - Cellular and molecular …, 2011 - Springer
Cannabidiol (CBD) is a non-psychoactive plant cannabinoid that is clinically used in a 1: 1
mixture with the psychoactive cannabinoid Δ 9-tetrahydrocannabinol (THC) for the treatment …

An evaluation of the anti‐hyperalgesic effects of cannabidiolic acid‐methyl ester in a preclinical model of peripheral neuropathic pain

YF Zhu, K Linher‐Melville, MJ Niazmand… - British journal of …, 2020 - Wiley Online Library
Background and Purpose Chronic neuropathic pain (NEP) is associated with growing
therapeutic cannabis use. To promote quality of life without psychotropic effects …

Evaluation of the preclinical analgesic efficacy of naturally derived, orally administered oil forms of Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD), and their 1: 1 …

K Linher-Melville, YF Zhu, J Sidhu, N Parzei… - PLoS …, 2020 - journals.plos.org
Chronic neuropathic pain (NP) is a growing clinical problem for which effective treatments,
aside from non-steroidal anti-inflammatory drugs and opioids, are lacking. Cannabinoids are …

[HTML][HTML] The molecular mechanisms that underpin the biological benefits of full-spectrum cannabis extract in the treatment of neuropathic pain and inflammation

ZH Maayah, S Takahara, M Ferdaoussi… - Biochimica et Biophysica …, 2020 - Elsevier
Cannabis has been shown to be beneficial in the treatment of pain and inflammatory
diseases. The biological effect of cannabis is mainly attributed to two major cannabinoids …