ATM (ataxia-telangiectasia mutated) is a PI3K-like kinase best known for its role in the DNA
damage response (DDR), especially after double-strand breaks. Mutations in the ATM gene …

The autosomal recessive genome instability disorder Ataxia–telangiectasia, caused by
mutations in ATM kinase, is characterized by the progressive loss of cerebellar neurons. We …

The protein kinase ATM (ataxia-telangiectasia mutated) activates the cellular response to
double strand breaks (DSBs), a highly cytotoxic DNA lesion. ATM is activated by DSBs and …

To investigate the mechanistic basis for central nervous system (CNS) neurodegeneration in
the disease ataxia–telangiectasia (AT), we analyzed flies mutant for the causative gene AT …

Ataxia‐telangiectasia (A‐T) is characterized by neuronal degeneration, cancer, diabetes,
immune deficiency, and increased sensitivity to ionizing radiation. A‐T is attributed to the …

Dysfunction in Ataxia-telangiectasia mutated (ATM), a central component of the DNA repair
machinery, results in Ataxia Telangiectasia (AT), a cancer-prone disease with a variety of …

Appropriate cellular signaling responses to DNA damage and the ability to repair DNA are
fundamental processes that are required for organismal survival. Ataxia-telangiectasia (AT) …

ATM is a PI 3-kinase involved in DNA double-strand break repair. ATM deficiency leads to
ataxia-telangiectasia (AT), a syndrome of cancer susceptibility, hypersensitivity to ionizing …

This workshop on ataxia-telangiectasia marked the tenth anniversary of the discovery of the
gene that is defective in this syndrome—that is, ataxia-telangiectasia mutated (ATM; Savitsky …

ATM (ataxia-telangiectasia mutated) is a large protein kinase whose best-known function is
as a participant in the process of DNA damage repair, specifically lesions that result in …