Research into the biosynthesis of C11-oxy C 19 steroids during human fetal development,
specifically fetal adrenal development and during the critical period of sex differentiation, is …

Adrenal steroidogenesis has, for decades, been depicted as three biosynthesis pathways–
the mineralocorticoid, glucocorticoid and androgen pathways with aldosterone, cortisol and …

The purpose of this study was to identify the C11-oxy C 19 and C11-oxy C 21 steroids in
male and female neonate plasma. At birth, the most abundant C11-oxy steroids detected in …

It is widely believed that adrenal tumours and ovarian luteomas in pregnant women cause
virilisation of female foetuses through overproduction of testosterone and/or …

In the present study an ultra-performance convergence chromatography tandem mass
spectrometry (UPC 2-MS/MS) analytical method was developed and validated for the …

Hydroxylase deficiency presents with increased levels of cytochrome P450 21‐hydroxylase
substrates, progesterone and 17α-hydroxyprogesterone, which have been implicated in the …

Zebrafish are widely used as model organism. Their suitability for endocrine studies, drug
screening and toxicity assessements depends on the extent of conservation of specific …

Human fetal gonads acquire endocrine steroidogenic capabilities early during their
differentiation. Genetic studies show that this endocrine function plays a central role in the …

The abundant adrenal C19 steroid 11β-hydroxyandrostenedione (11OHA4) has been
written off as a dead-end product of adrenal steroidogenesis. However, recent evidence has …

Scientific evidence related to the aromatase reaction in various biological processes
spanning from mid-1960 to today is abundant; however, as our analytical sensitivity …