Heightened lactate production in cancer cells has been linked to various cellular
mechanisms such as angiogenesis, hypoxia, macrophage polarisation and T‐cell …

Histone lactylation, an indicator of lactate level and glycolysis, has intrinsic connections with
cell metabolism that represents a novel epigenetic code affecting the fate of cells including …

As a major product of glycolysis and a vital signaling molecule, many studies have reported
the key role of lactate in tumor progression and cell fate determination. Lactylation is a newly …

Lactate is a glycolytic product and a significant energy source. Moreover, it regulates gene
transcription via lactylation of histones and non-histone proteins, ie, a novel posttranslational …

Abstract The Warburg Effect is one of the most well-known cancer hallmarks. This metabolic
pattern centered on lactate has extremely complex effects on various aspects of tumor …

Background Lactate is an important metabolite derived from glycolysis under physiological
and pathological conditions. The Warburg effect reveals the vital role of lactate in cancer …

Lactate was once considered to be a by‐product of energy metabolism, but its unique
biological value was only gradually explored with the advent of the Warburg effect. As an …

Significance: Metabolic end products and intermediates can exert signaling functions as
chemical sources for histone posttranslational modifications, which remodel chromatin and …

Lactate is not only an endpoint of glycolysis but is gradually being discovered to play the
role of a universal metabolic fuel for energy via the 'lactate shuttle'moving between cells and …

There is growing evidence that lactate can have a wide range of biological impacts in
addition to being a waste product of metabolism. Because of the Warburg effect, tumors …