Safety of direct oral anticoagulants in real–world clinical practice: translating the trials to everyday clinical management

AM Fawzy, WY Yang, GYH Lip - Expert Opinion on Drug Safety, 2019 - Taylor & Francis
ABSTRACT Introduction: Direct oral anticoagulants (DOACs) may be regarded as some of
the most successful innovations in recent times. These drugs which were specifically …

Comparative effectiveness and safety of direct oral anticoagulants: overview of systematic reviews

E Raschi, M Bianchin, M Gatti, A Squizzato, F De Ponti - Drug Safety, 2019 - Springer
Direct oral anticoagulants are now recommended by major guidelines as first-choice agents
for both stroke prevention in non-valvular atrial fibrillation and treatment/prevention of …

[HTML][HTML] Risk–benefit profile of direct-acting oral anticoagulants in established therapeutic indications: an overview of systematic reviews and observational studies

E Raschi, M Bianchin, W Ageno, R De Ponti, F De Ponti - Drug safety, 2016 - Springer
Since 2008, the direct-acting oral anticoagulants (DOACs) have expanded the therapeutic
options of cardiovascular diseases with recognized clinical and epidemiological impact …

Emerging therapeutic uses of direct-acting oral anticoagulants: an evidence-based perspective

E Raschi, M Bianchin, R De Ponti, F De Ponti… - Pharmacological …, 2017 - Elsevier
Direct-acting oral anticoagulants (DOACs) were claimed to cause a potential paradigm shift
in the therapeutic scenario of patients requiring short-and long-term anticoagulation, by …

[PDF][PDF] Adverse events associated with the use of direct-acting oral anticoagulants in clinical practice: beyond bleeding complications

E Raschi, M Bianchin, W Ageno, R De Ponti… - Pol Arch Med …, 2016 - researchgate.net
Non-vitamin K oral anticoagulants, also known as direct-acting oral anticoagulants (DOACs),
have entered the market in 2008 with the expected breakthrough potential of circumventing …

It's time for head-to-head trials with direct oral anticoagulants

T Tritschler, LA Castellucci - Thrombosis research, 2019 - Elsevier
Direct oral anticoagulants (DOACs) have become the recommended first choice
anticoagulant agent for treatment of acute venous thromboembolism (VTE) in non-cancer …

[HTML][HTML] Safety of direct oral anticoagulants: insights from postmarketing studies

TC Villines, WF Peacock - The American Journal of Medicine, 2016 - Elsevier
Direct oral anticoagulants (DOACs) have been marketed in the United States since 2010.
While numerous large-scale prospective phase 3 outcomes studies have documented the …

Comparative effectiveness and safety of low-strength and high-strength direct oral anticoagulants compared with warfarin: a sequential cohort study

NL Pratt, E Ramsay, LMK Ellett, K Duszynski… - BMJ open, 2019 - bmjopen.bmj.com
Objectives The aim of this study was to compare effectiveness and safety of low-strength and
high-strength direct oral anticoagulants (DOACs) with warfarin in the Australian Veteran …

Safety profile of the direct oral anticoagulants: an analysis of the WHO database of adverse drug reactions

L Monaco, C Biagi, V Conti, M Melis… - British journal of …, 2017 - Wiley Online Library
Aim Direct oral anticoagulants (DOACs) have shown noninferiority to warfarin for stroke
prevention in nonvalvular atrial fibrillation (AF) and a more promising safety profile …

[HTML][HTML] Direct oral anticoagulants: a quick guide

S Julia, U James - European Cardiology Review, 2017 - ncbi.nlm.nih.gov
Vitamin K antagonists, such as warfarin, have been the anticoagulants of choice for many
years for patients with AF and other thrombotic conditions. The introduction of direct oral …