The development of effective vaccines hinges upon the inclusion of an appropriate
immunopotentiator or adjuvant to enhance both cellular and humoral immune responses …

New generation vaccines such as recombinant, antigen purified and DNA vaccines are
poorly immunogenic due to the lack of an innate immune stimulus. Therefore, search of new …

Saponins are natural glycosides of steroid or triterpene which exhibited many different
biological and pharmacological activities. Notably, saponins can also activate the …

Protopanaxadiol saponins (Rg3, Rd, Rc, Rb1 and Rb2) and protopanaxatriol saponins
(Rg1, Re and Rg2) isolated from the root of Panax ginseng CA Meyer were evaluated for …

Vaccine adjuvants are key for optimal vaccine efficacy, increasing the immunogenicity of the
antigen and potentiating the immune response. Saponin adjuvants such as the …

Eight pure triterpenoid saponin compounds isolated from the root of Polygala senega L., a
plant indigenous to the Canadian prairies, were evaluated for their immunological activity in …

Naturally occurring triterpene glycosides (saponins) from Quillaja saponaria have
considerable adjuvant activity. Adjuvant functions include stimulation of high levels of …

We have prepared a number of saponin-based vaccine adjuvant candidates. These
unnatural saponins have a different terminal-functionalized side chain incorporated into the …

Extracts from the Quillaja saponaria tree are known to provide immune potentiating
responses and, hence, can be useful as adjuvants. Partial purification from the crude (food …

Four protopanaxadiol-type saponins (PDS), ginsenosides-Rb1,-Rd, notoginsenosides-K,-R4
isolated from the roots of Panax notoginseng were evaluated for their haemolytic activities …