Introduction Tobacco smoking generates airway inflammation in chronic obstructive
pulmonary disease (COPD), and its involvement in the development of lung cancer is still …

Background CD8+ T cells (Cytotoxic T cells, Tc) are known to play a critical role in the
pathogenesis of smoking related airway inflammation including chronic obstructive …

Background CD4+ T cells in the lung are involved in the pathogenesis of chronic obstructive
pulmonary disease (COPD), although CD4+ T cell subsets and the direct effect of smoking …

Background The temporally dynamic changes of CD25 and Foxp3 expression in CD4+ T
cells are initiated by T cell receptor (TCR) signals strength or frequency. There is a …

Abstract Background Chronic Obstructive Pulmonary Disease (COPD) is associated with an
abnormal pulmonary and systemic immune response to tobacco smoking. Yet, how do …

Rationale: Despite the importance of inflammation in chronic obstructive pulmonary disease
(COPD), the immune cell landscape in the lung tissue of patients with mild-moderate …

Chronic obstructive pulmonary disease (COPD) is a complex chronic disease in which T cell-
mediated pulmonary inflammation has been shown to play a key role. Accumulating …

BACKGROUND: Recent studies have revealed that autoimmune responses mediated by
CD4+ T cells may contribute to the development of chronic obstructive pulmonary disease …

CD8 cells may contribute towards an autoimmune process in COPD. Down regulation of T
cell receptor (TCR) signalling molecules occurs in autoimmune diseases with consequent T …

Background The imbalance between pro-and anti-inflammatory immune responses plays a
pivotal role in chronic obstructive pulmonary disease (COPD) development and progression …