Background Hypoxia is associated with a poor prognosis in prostate cancer. This work
aimed to derive and validate a hypoxia-related mRNA signature for localized prostate …

Prostate cancer cells exist under hypoxic conditions. Hypoxia has a detrimental effect on the
efficacy of treatment and final outcome in patients with prostate cancer. There have been a …

Introduction• Pathological markers of hypoxia‐Necrosis‐Hypoxia inducible factor (HIF)
targets‐HIF‐1 versus HIF‐2‐Early versus late stage cancer‐Intratumour heterogeneity …

BACKGROUND AND PURPOSE: Hypoxia is a common feature of solid tumors associated
with therapy resistance, increased malignancy and poor prognosis. Several approaches …

Hypoxia is a feature of most solid tumours and is associated with a poor prognosis. The
hypoxic environment can reduce the efficacy of radiotherapy and some chemotherapeutics …

Background Expression of intrinsic markers of tumour hypoxia and angiogenesis are
important predictors of radiotherapeutic, and possibly surgical, outcome in several cancers …

Purpose: Hypoxia modification improves overall survival in muscle-invasive bladder cancer
patients who undergo radiotherapy. There is evidence that hypoxic tumors benefit most from …

Background Increasing evidence has shown that hypoxia microenvironment relates to tumor
initiation and progression. However, no studies focus on the application of hypoxia …

Increasingly, the tumor microenvironment and hypoxia are being studied as potential
prognostic factors in prostate cancer given their effects on the hypoxia inducible factor-1α …

Background: The hypoxia marker pimonidazole is a candidate biomarker of cancer
aggressiveness. We investigated the transcriptional programme associated with …