The reaction of hydroxyl radical (OH•) with DNA accounts for about half of radiation-induced
DNA damage in living systems. Previous literature reports point out that the reaction of OH• …

Mechanisms of formation of the mutagenic product 8-oxoguanine (8OG) due to reactions of
guanine with two separate OH• radicals and with H2O2 were investigated at the B3LYP/6 …

Thermodynamic and kinetic calculations have been used to reinterpret the UV− vis data
related to the OH radical oxidation of guanosine. The main channel of reaction (70− 75%) is …

The addition as well as abstraction reactions of hydroxyl radical (OH) with the nucleic acid
base, uracil (U), in the gas phase has been explored at the B3LYP/6-31+ G (d, p) level of …

Direct and indirect radiation-induced DNA damage is associated with the formation of
radical cations (G•+) and radical anions (G•−) of guanine, respectively. Deprotonation of G•+ …

Oxidation of guanine in DNA yields the nucleobase damage product 8-oxoguanine (8-
oxoG), whose further oxidation gives other more stable products. In the present study, the …

The reaction of hydroxyl radical (• OH) with guanine was investigated under restricted pH
condition (pH 4.6) using pulse radiolysis technique. The time-resolved optical transient …

Understanding the basic chemistry of the interaction of radicals with DNA bases is
imperative when trying to predict the potential effects of radiation on DNA. Experimental …

Upon one-electron oxidation, all molecules including DNA bases become more acidic in
nature. For the GC base pair, experiments suggest that a facile proton transfer takes place in …

Reactions of radicals of the DNA bases with reactive oxygen species and reactive nitrogen
oxide species produce mutagenic products. We have studied reactivities of all the carbon …