Changes of immunocytic phenotypes and functions from human colorectal adenomatous stage to cancerous stage: Update

Y Shi, Z Li, W Zheng, X Liu, C Sun, JB Laugsand, Z Liu… - Immunobiology, 2015 - Elsevier
It is believed that chronic inflammation as seen in patients with ulcerative colitis significantly
increases the colorectal cancer (CRC) risk and functions as the main driving force for the …

Immune microenvironmental shift along human colorectal adenoma–carcinoma sequence: is it relevant to tumor development, biomarkers and biotherapeutic targets?

G Cui, Y Shi, J Cui, F Tang… - Scandinavian journal of …, 2012 - Taylor & Francis
Human colorectal carcinoma (CRC) is one of the leading cancers. Every year, the WHO
estimates a total of 945,000 new CRC cases, with 492,000 deaths worldwide. Most CRCs …

The role of inflammatory cytokines in the pathogenesis of colorectal carcinoma—recent findings and review

J Borowczak, K Szczerbowski, M Maniewski… - Biomedicines, 2022 - mdpi.com
The inflammatory process plays a significant role in the development of colon cancer (CRC).
Intestinal cytokine networks are critical mediators of tissue homeostasis and inflammation …

The association of immune cell infiltration and prognosis in colorectal cancer

R Palmqvist, ML Wikberg, A Ling, S Edin - Current colorectal cancer …, 2013 - Springer
Colorectal cancer is one of the leading causes of cancer-related deaths worldwide. The
tumor microenvironment is of great biological importance in cancer development and …

The dual role of inflammation in colon carcinogenesis

G Monteleone, F Pallone, C Stolfi - International Journal of Molecular …, 2012 - mdpi.com
Chronic inflammation characterizing patients with inflammatory bowel disease (IBD)
represents a major risk factor for the development of colorectal cancer. Mechanisms …

Differential Immune Infiltration Profiles in Colitis-Associated Colorectal Cancer versus Sporadic Colorectal Cancer

J Schardey, C Lu, J Neumann, U Wirth, Q Li, T Jiang… - Cancers, 2023 - mdpi.com
Simple Summary Chronic inflammation plays a significant role in colorectal cancer (CRC)
development, particularly in colitis-associated CRC (CAC). This study examined immune …

The inflammatory microenvironment in colorectal neoplasia

MH McLean, GI Murray, KN Stewart, G Norrie… - PLoS …, 2011 - journals.plos.org
Colorectal cancer (CRC) is a major cause of mortality and morbidity worldwide. Inflammatory
activity within the stroma of invasive colorectal tumours is known to be a key predictor of …

[HTML][HTML] Intestinal inflammation and colorectal cancer: a double-edged sword?

A Rizzo, F Pallone, G Monteleone… - World journal of …, 2011 - ncbi.nlm.nih.gov
Chronic inflammation is thought to be the leading cause of many human cancers including
colorectal cancer (CRC). Accordingly, epidemiologic and clinical studies indicate that …

Inflammation and colorectal cancer: colitis-associated neoplasia

SI Grivennikov - Seminars in immunopathology, 2013 - Springer
Connection between inflammation and cancer is a rapidly developing field. Epidemiological
data suggests that inflammation along with distinct arms of host immune system plays a very …

[HTML][HTML] Mechanistic roles of epithelial and immune cell signaling during the development of colitis-associated cancer

R Subramaniam, A Mizoguchi… - Cancer research …, 2016 - ncbi.nlm.nih.gov
To date, substantial evidence has shown a significant association between inflammatory
bowel diseases (IBD) and development of colitis-associated cancer (CAC). The …