Individual characterization of stably expanded T cell clones in ankylosing spondylitis patients
IZ Mamedov, OV Britanova, AV Chkalina… - …, 2009 - Taylor & Francis
Ankylosing spondylitis (AS) is commonly characterized by clonal expansions of T cells.
However, these clonal populations are poorly studied and their role in disease initiation and …
However, these clonal populations are poorly studied and their role in disease initiation and …
[HTML][HTML] TCR repertoire and CDR3 motif analyses depict the role of αβ T cells in Ankylosing spondylitis
M Zheng, X Zhang, Y Zhou, J Tang, Q Han, Y Zhang… - …, 2019 - thelancet.com
Background Ankylosing spondylitis (AS) is a chronic inflammatory disease with worldwide
high prevalence. Although AS is strongly associated with HLA-B27 MHC-I antigen …
high prevalence. Although AS is strongly associated with HLA-B27 MHC-I antigen …
[引用][C] T‐cell receptor immunosequencing reveals altered repertoire diversity and disease‐associated clonal expansions in ankylosing spondylitis patients
AL Hanson, HJ Nel, L Bradbury… - Arthritis and …, 2020 - espace.library.uq.edu.au
Ankylosing spondylitis (AS) is a common spondyloarthropathy primarily affecting the axial
skeleton and strongly associated with HLA-B* 27 carriage. Genetic evidence implicates both …
skeleton and strongly associated with HLA-B* 27 carriage. Genetic evidence implicates both …
Characterization of peripheral blood TCR repertoire in patients with ankylosing spondylitis by high-throughput sequencing
JH Cui, Y Jin, KR Lin, P Xiao, X Chen, Y Pan, W Lin… - Human Immunology, 2018 - Elsevier
Ankylosing spondylitis (AS) is a chronic and progressive autoimmune disease affecting the
invasion of the spine, sacroiliac joints and peripheral joints. T cells play a vital role in the …
invasion of the spine, sacroiliac joints and peripheral joints. T cells play a vital role in the …
Altered Repertoire Diversity and Disease‐Associated Clonal Expansions Revealed by T Cell Receptor Immunosequencing in Ankylosing Spondylitis Patients
AL Hanson, HJ Nel, L Bradbury, J Phipps… - Arthritis & …, 2020 - Wiley Online Library
Objective Ankylosing spondylitis (AS) is a common spondyloarthropathy primarily affecting
the axial skeleton and strongly associated with HLA–B* 27 carriage. Genetic evidence …
the axial skeleton and strongly associated with HLA–B* 27 carriage. Genetic evidence …
CD8+ T cells with characteristic T cell receptor beta motif are detected in blood and expanded in synovial fluid of ankylosing spondylitis patients
Objective The risk of AS is associated with genomic variants related to antigen presentation
and specific cytokine signalling pathways, suggesting the involvement of cellular immunity in …
and specific cytokine signalling pathways, suggesting the involvement of cellular immunity in …
[HTML][HTML] TCR repertoire profiling revealed antigen-driven CD8+ T cell clonal groups shared in synovial fluid of patients with spondyloarthritis
EA Komech, AD Koltakova, AA Barinova… - Frontiers in …, 2022 - frontiersin.org
Spondyloarthritis (SpA) comprises a number of inflammatory rheumatic diseases with
overlapping clinical manifestations. Strong association with several HLA-I alleles and T cell …
overlapping clinical manifestations. Strong association with several HLA-I alleles and T cell …
CD4+ and CD8+ clonal T cell expansions indicate a role of antigens inankylosing spondylitis; a study in HLA-B27+ monozygotic twins
R Duchmann, C Lambert, E May… - Clinical & …, 2001 - academic.oup.com
Ankylosing spondylitis (AS) is a complex genetic disease in which both MHC and non-MHC
genes determine disease susceptibility. To determine whether the T cell repertoires of …
genes determine disease susceptibility. To determine whether the T cell repertoires of …
CD8+ T cells oligoclonally expanded in synovial fluid at onset of spondyloarthropathy selectively proliferate in response to self-antigens: characterization of cell …
MA Treviño, E Teixeiro, R Bragado - The Journal of rheumatology, 2004 - jrheum.org
OBJECTIVE: To characterize putative T cells responsible for the pathogenesis of
spondyloarthropathies (SpA). METHODS: T cells from synovial fluid (SF) and peripheral …
spondyloarthropathies (SpA). METHODS: T cells from synovial fluid (SF) and peripheral …
[HTML][HTML] Circulating cytotoxic CD8+ CD28- T cells in ankylosing spondylitis
M Schirmer, C Goldberger, R Würzner… - Arthritis Research & …, 2001 - Springer
Abstract Circulating CD8+ CD28-T cells were found to be expanded more in patients with
ankylosing spondylitis than in an age-matched healthy population (41.2±17.7% versus …
ankylosing spondylitis than in an age-matched healthy population (41.2±17.7% versus …