Pancreatic b-cell failure, alongside insulin resistance, can be considered as one of the two
key events that leads to the development of type 2 diabetes (Leahy et al. 2010). In the early …

Type 2 diabetes mellitus is a complex disease characterized by β-cell failure in the setting of
insulin resistance. In early stages of the disease, pancreatic β-cells adapt to insulin …

Type 2 diabetes (T2DM) is characterized by insulin resistance and beta-cell dysfunction.
Although insulin resistance is assumed to be a main pathophysiological feature of the …

Adipose tissue evolved to efficiently store energy for times of caloric restriction. The large
caloric excess common in many Western diets has negated the need for this thrifty function …

Obesity-linked type 2 diabetes is a disease of insulin resistance combined with pancreatic β-
cell dysfunction. Although a role for β-cell mass in the pathogenesis of obesity-linked type 2 …

In addition to serving as an energy reservoir, the adipocyte has been characterized as an
endocrine cell, secreting many bioactive factors which influence energy homeostasis. Being …

The past two decades have seen an explosive increase in the number of people diagnosed
with diabetes mellitus worldwide, particularly type 2 diabetes (T2D), which is found …

Like the obesity epidemic, our understanding of adipocytes and adipose tissue is
expanding. Just in the past decade, substantial advances have led to new insights into the …

Background: In most individuals, the need to respond to progressive states of insulin
resistance is met by increasing insulin production. For insulin-resistant patients, however …

It is now well accepted that diabetes mellitus is one of the main threats to human health in
the twenty-first century. The total number of people with diabetes worldwide was estimated …