Alzheimer's disease (AD) is one of the most common neurodegenerative diseases
worldwide. The occult nature of the onset and the uncertainty of the etiology largely impede …

To maintain energy supply to the brain, a direct energy source called adenosine
triphosphate (ATP) is produced by oxidative phosphorylation and aerobic glycolysis of …

Alzheimer's disease (AD) is the most common form of dementia in old age. Cognitive
impairment in AD may be partially due to overall hypometabolism. Indeed, AD is …

Diminished glucose metabolism accompanies many neurodegenerative diseases including
Alzheimer's disease. An understanding of the relation of these metabolic changes to the …

Over the last century, there has been a gradual but sustained increase in life expectancy
globally. A consequence of increased life expectancy is an associated rise in the prevalence …

The brain is a highly dynamic organ that requires a constant energy source to function
normally. This energy is mostly supplied by glucose, a simple sugar that serves as the …

A central issue in the field of Alzheimer's disease (AD) is to separate the cause from the
consequence among many observed pathological features, which may be resolved by …

Alzheimer's disease (AD) is an incurable neurodegenerative disease. Numerous studies
have demonstrated a critical role for dysregulated glucose metabolism in its pathogenesis …

Alzheimer's disease (AD) is an irreversible, progressive disease that slowly destroys
cognitive function, such as thinking, remembering, and reasoning, to a level that one cannot …

Significance: Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder and
represents one of the most disabling conditions. AD shares many features in common with …