[HTML][HTML] Enhanced cerebral hemodynamics and cognitive function via knockout of dual-specificity protein phosphatase 5

H Zhang, JJ Border, X Fang, Y Liu, C Tang… - Journal of pharmacy …, 2023 - ncbi.nlm.nih.gov
Alzheimer's Disease (AD) and Alzheimer's Disease-Related Dementias (ADRD) are
neurodegenerative disorders. Recent studies suggest that cerebral hypoperfusion is an …

Impact of knockout of dual-specificity protein phosphatase 5 on structural and mechanical properties of rat middle cerebral arteries: implications for vascular aging

C Tang, H Zhang, JJ Border, Y Liu, X Fang… - GeroScience, 2024 - Springer
Vascular aging influences hemodynamics, elevating risks for vascular diseases and
dementia. We recently demonstrated that knockout (KO) of Dusp5 enhances cerebral and …

[HTML][HTML] Role of Dusp5 KO on Vascular Properties of Middle Cerebral Artery in Rats

C Tang, H Zhang, JJ Border, Y Liu, X Fang… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Vascular aging influences hemodynamics, elevating risks for vascular diseases and
dementia. We recently demonstrated that knockout (KO) of Dusp5 enhances cerebral and …

Influence of dual‐specificity protein phosphatase 5 on mechanical properties of rat cerebral and renal arterioles

H Zhang, C Zhang, Y Liu, W Gao, S Wang… - Physiological …, 2020 - Wiley Online Library
We recently reported that KO of Dual‐specificity protein phosphatase 5 (Dusp5) enhances
myogenic reactivity and blood flow autoregulation in the cerebral and renal circulations in …

Phosphatase 2A inhibition affects endoplasmic reticulum and mitochondria homeostasis via cytoskeletal alterations in brain endothelial cells

AI Plácido, CMF Pereira, SC Correira, C Carvalho… - Molecular …, 2017 - Springer
The loss of endothelial cells (ECs) homeostasis is a trigger for cerebrovascular dysfunction
that is a common event in several neurodegenerative disorders such as Alzheimer's disease …

Knockout of dual-specificity protein phosphatase 5 protects against hypertension-induced renal injury

C Zhang, X He, SR Murphy, H Zhang, S Wang… - … of Pharmacology and …, 2019 - ASPET
Dual-specificity protein phosphatase 5 (DUSP5) is a member of the tyrosine-threonine
phosphatase family with the ability to dephosphorylate and inactivate extracellular signal …

Zinc-Finger Nuclease Knockout of Dual-Specificity Protein Phosphatase-5 Enhances the Myogenic Response and Autoregulation of Cerebral Blood Flow in FHH.1BN …

F Fan, AM Geurts, MR Pabbidi, SV Smith, DR Harder… - PloS one, 2014 - journals.plos.org
We recently reported that the myogenic responses of the renal afferent arteriole (Af-Art) and
middle cerebral artery (MCA) and autoregulation of renal and cerebral blood flow (RBF and …

DUSP10 alleviates ischemic stroke-induced neuronal damage by restricting p38/JNK pathway

NN Song, Y Zhao, C Sun, J Zhang, GJ Lin… - Behavioural Brain …, 2023 - Elsevier
Neuronal apoptosis is considered one of the hallmarks of ischemic stroke. Dual specificity
phosphatase 10 (DUSP10), a member of the dual-specificity phosphatase family, which is …

Increasing expression of dual-specificity phosphatase 12 mitigates oxygen-glucose deprivation/reoxygenation-induced neuronal apoptosis and inflammation through …

J He, S Li, Y Teng, H Xiong, Z Wang, X Han… - …, 2024 - Taylor & Francis
Abstract Dual-specificity phosphatase 12 (DUSP12) is abnormally expressed under various
pathological conditions and plays a crucial role in the pathological progression of disorders …

Dual-specificity phosphatase 26-dificient neurons are susceptible to oxygen-glucose deprivation/reoxygenation-evoked apoptosis and proinflammatory response by …

H Zhao, J Lv, L Meng, J Lv, Z Li - International Immunopharmacology, 2023 - Elsevier
Abstract Dual-specificity phosphatase 26 (DUSP26) is linked to a broad range of human
disorders as it affects numerous signaling cascades. However, the involvement of DUSP26 …