Pan-cancer single-cell landscape of tumor-infiltrating T cells
INTRODUCTION Cancer immunotherapies that target tumor-specific T cells have benefited
many cancer patients, but the clinical efficacy varies greatly among different cancer types …
many cancer patients, but the clinical efficacy varies greatly among different cancer types …
[HTML][HTML] Single-cell transcriptomics of human T cells reveals tissue and activation signatures in health and disease
Human T cells coordinate adaptive immunity in diverse anatomic compartments through
production of cytokines and effector molecules, but it is unclear how tissue site influences T …
production of cytokines and effector molecules, but it is unclear how tissue site influences T …
TISCH: a comprehensive web resource enabling interactive single-cell transcriptome visualization of tumor microenvironment
Cancer immunotherapy targeting co-inhibitory pathways by checkpoint blockade shows
remarkable efficacy in a variety of cancer types. However, only a minority of patients respond …
remarkable efficacy in a variety of cancer types. However, only a minority of patients respond …
[HTML][HTML] Technology meets TILs: Deciphering T cell function in the-omics era
T cells are at the center of cancer immunology because of their ability to recognize mutations
in tumor cells and directly mediate cancer cell killing. Immunotherapies to rejuvenate …
in tumor cells and directly mediate cancer cell killing. Immunotherapies to rejuvenate …
TISCH2: expanded datasets and new tools for single-cell transcriptome analyses of the tumor microenvironment
Abstract The Tumor Immune Single Cell Hub 2 (TISCH2) is a resource of single-cell RNA-
seq (scRNA-seq) data from human and mouse tumors, which enables comprehensive …
seq (scRNA-seq) data from human and mouse tumors, which enables comprehensive …
[HTML][HTML] Single-cell transcriptome and antigen-immunoglobin analysis reveals the diversity of B cells in non-small cell lung cancer
Background Malignant transformation and progression of cancer are driven by the co-
evolution of cancer cells and their dysregulated tumor microenvironment (TME). Recent …
evolution of cancer cells and their dysregulated tumor microenvironment (TME). Recent …
Recharacterizing tumor-infiltrating lymphocytes by single-cell RNA sequencing
T cells are central players in cancer immunotherapy. Despite much concentrated effort on
the study of tumor-infiltrating lymphocytes (TIL), such as T cells, a series of fundamental …
the study of tumor-infiltrating lymphocytes (TIL), such as T cells, a series of fundamental …
[HTML][HTML] Single-cell sequencing links multiregional immune landscapes and tissue-resident T cells in ccRCC to tumor topology and therapy efficacy
C Krishna, RG DiNatale, F Kuo, RM Srivastava… - Cancer cell, 2021 - cell.com
Clear cell renal cell carcinomas (ccRCCs) are highly immune infiltrated, but the effect of
immune heterogeneity on clinical outcome in ccRCC has not been fully characterized. Here …
immune heterogeneity on clinical outcome in ccRCC has not been fully characterized. Here …
Molecular signatures of antitumor neoantigen-reactive T cells from metastatic human cancers
The accurate identification of antitumor T cell receptors (TCRs) represents a major challenge
for the engineering of cell-based cancer immunotherapies. By mapping 55 neoantigen …
for the engineering of cell-based cancer immunotherapies. By mapping 55 neoantigen …
[HTML][HTML] Lineage tracing reveals clonal progenitors and long-term persistence of tumor-specific T cells during immune checkpoint blockade
Paired single-cell RNA and T cell receptor sequencing (scRNA/TCR-seq) has allowed for
enhanced resolution of clonal T cell dynamics in cancer. Here, we report a scRNA/TCR-seq …
enhanced resolution of clonal T cell dynamics in cancer. Here, we report a scRNA/TCR-seq …