Pain is ultimately a perceptual phenomenon. It is built from information gathered by
specialized pain receptors in tissue, modified by spinal and supraspinal mechanisms, and …

Chronic pain is a maladaptive neurological disease that remains a major health problem. A
deepening of our knowledge on mechanisms that cause pain is a prerequisite to developing …

Chronic pain is a global problem that has reached epidemic proportions. An estimated 20%
of adults suffer from pain, and another 10% are diagnosed with chronic pain each year …

Pain is a clinical syndrome arising from a variety of etiologies in a heterogeneous
population, which makes successfully treating the individual patient difficult. Organizations …

Despite the myriad promising new targets and candidate analgesics recently identified in
preclinical pain studies, little translation to novel pain medications has been generated. The …

The use of genetically manipulated animals in conjunction with classical physiological and
biochemical measurement has unravelled many pathological changes in animal models of …

Many are frustrated with the lack of translational progress in the pain field, in which huge
gains in basic science knowledge obtained using animal models have not led to the …

For decades, basic research on the underlying mechanisms of nociception has held promise
to translate into efficacious treatments for patients with pain. Despite great improvement in …

Best practices in preclinical algesiometry (pain behaviour testing) have shifted over the past
decade as a result of technological advancements, the continued dearth of translational …

The current gap between basic science research and the development of new analgesics
presents a serious challenge for the future of pain medicine. This challenge is particularly …